References

Department of Ophthalmology, Hokkaido University

  1. Hirose S, Saito W, Yoshida K, Saito M, Dong Z, Namba K, Satoh H, Ohno S.
    Elevated choroidal blood flow velocity during systemic corticosteroidtherapy in Vogt-Koyanagi-Harada disease
    Acta Ophthalmol. 2008 Dec;86(8):902-7. Epub 2008 Nov 12. doi:10.1111/j.1755-3768.2008.01384.x [Link]
  2. Michiyuki Saito, Kazuhiko Yoshida, Wataru Saito, Akio Fujiya, Kazuhiro Ohgami, Nobuyoshi Kitaichi, Hiroki Tsukahara, Susumu Ishida and Shigeaki Ohno
    Astaxanthin increases choroidal blood flow velocity
    Graefe's Archive for Clinical and Experimental Ophthalmology ,Vol.250, No.2, 239-245, DOI: 10.1007/s00417-011-1843-1, 2012. [Link]
  3. Hashimoto Y, Saito W, Mori S, Saito M, Ishida S
    Increased macular choroidal blood flow velocity during systemic corticosteroid therapy in a patient with acute macular neuroretinopathy
    Clinical Ophthalmology, 2012:6, 1645-1649 doi:10.2147/OPTH.S35854 [Link]
  4. Michiyuki Saito, Wataru Saito, Yuki Hashimoto, Chikako Yoshizawa, Akio Fujiya, Kousuke Noda, Susumu Ishida
    Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy
    Br J Ophthalmol doi:10.1136/bjophthalmol-2012-302349 [Link]
  5. Kiriko Hirooka, Wataru Saito, Kousuke Noda and Susumu Ishida
    Enhanced-depth Imaging Optical Coherence Tomography and Laser Speckle Flowgraphy in a Patient with Acute Macular Neuroretinopathy
    Ocular Immunology & Inflammation, (0), 1-5, 2014. doi:10.3109/09273948.2014.916305 [Link]
  6. Kiriko Hirooka, Wataru Saito, Yuki Hashimoto, Michiyuki Saito and Susumu Ishida
    Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy
    BMC Ophthalmology, 14(1), 73, 2014. doi:10.1186/1471-2415-14-73 [Link]
  7. Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda and Susumu Ishida
    Decreased choroidal blood flow velocity in the pathogenesis of multiple evanescent white dot syndrome
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2014, 1-8. doi:10.1007/s00417-014-2831-z [Link]
  8. Ai Takahashi, Wataru Saito, Yuki Hashimoto, Michiyuki Saito, Susumu Ishida
    Impaired Circulation in the Thickened Choroid of a Patient with Serpiginous Choroiditis
    Ocular Immunology and Inflammation, Posted online on April 11, 2014. doi:10.3109/09273948.2014.902075 [Link]
  9. Michiyuki Saito, Wataru Saito, Yuki Hashimoto, Chikako Yoshizawa, Yasuhiro Shinmei, Kousuke Noda, Susumu Ishida
    Correlation between decreased choroidal blood flow velocity and the pathogenesis of acute zonal occult outer retinopathy
    Clinical and Experimental Ophthalmology, DOI:10.1111/ceo.12143 [Link]
  10. Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda and Susumu Ishida
    Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy
    Japanese Journal of Ophthalmology, 2015, 1-9. doi:10.1007/s10384-015-0380-6 [Link]
  11. Michiyuki Saito, Wataru Saito, Kiriko Hirooka, Yuki Hashimoto, Shohei Mori, Kousuke Noda and Susumu Ishida
    Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy
    Investigative Ophthalmology & Visual Science, 56(11), 6515-6522, 2015. doi:10.1167/iovs.15-17246 [Link]
  12. Hirooka Kiriko, Saito Wataru, Namba Kenichi, Mizuuchi Kazuomi, Iwata Daiju, Hashimoto Yuki, Ishida Susumu
    Significant role of the choroidal outer layer during recovery from choroidal thickening in Vogt-Koyanagi-Harada disease patients treated with systemic corticosteroids
    BMC Ophthalmol, 15(1), Dec 2015. doi:10.1186/s12886-015-0171-3 [Link]
  13. Kiriko Hirooka, Wataru Saito, Kenichi Namba, Yuko Takemoto, Kazuomi Mizuuchi, Tomoe Uno, Yoshiaki Tagawa, Yuki Hashimoto and Susumu Ishida
    Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt–Koyanagi–Harada disease
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, 1-9. doi:10.1007/s00417-014-2927-5 [Link]
  14. Kiriko Hirooka, Wataru Saito , Michiyuki Saito, Yuki Hashimoto, Shohei Mori, Kousuke Noda and Susumu Ishida
    Increased choroidal blood flow velocity with regression of acute posterior multifocal placoid pigment epitheliopathy
    Japanese Journal of Ophthalmology, 2016, 1-7. doi:10.1007/s10384-016-0440-6 [Link]
  15. Yuko Takemoto, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Tomoe Uno, Shigeaki Ohno, Kiriko Hirooka, Yuki Hashimoto, Wataru Saito, Kazuhisa Sugiyama and Susumu Ishida
    Choroidal circulation impairment during the anterior recurrence of Vogt–Koyanagi–Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy
    Acta Ophthalmologica, 2016. doi:10.1111/aos.13024 [Link]
  16. Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa, Akari Takita, Shohei Mori, Kousuke Noda and Susumu Ishida
    Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy
    Journal of Ophthalmology, 2017. doi:10.1155/2017/2371032 [Link]
  17. Michiyuki Saito, Kousuke Noda, Wataru Saito and Susumu Ishida
    Relationship between choroidal blood flow velocity and choroidal thickness in patients with regression of acute central serous chorioretinopathy
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-017-3791-x, 2017. [Link]
  18. Akari Takita, Yuki Hashimoto, Wataru Saito, Satoru Kase and Susumu Ishida
    Changes in blood flow velocity and thickness of the choroid in a patient with leukemic retinopathy
    American journal of ophthalmology case reports, doi:10.1016/j.ajoc.2018.09.001, 2018. [Link]
  19. Iku Kikuchi, Satoru Kase, Yuki Hashimoto, Kiriko Hirooka and Susumu Ishida
    Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04257-7, 2019. [Link]
  20. Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa and Susumu Ishida
    Increased thickness and decreased blood flow velocity of the choroid in a patient with acute macular neuroretinopathy
    BMC Ophthalmology, 19:109, doi:10.1186/s12886-019-1123-0, 2019. [Link]
  21. Wataru Saito, Susumu Ishida
    Acute Zonal Occult Outer Retinopathy
    Inflammatory and Infectious Ocular Disorders. Retina Atlas., doi:10.1007/978-981-13-8546-9_6, 2019. [Link]
  22. Michiyuki Saito, Kousuke Noda, Wataru Saito, Kiriko Hirooka, Yuki Hashimoto and Susumu Ishida
    Increased choroidal blood flow and choroidal thickness in patients with hypertensive chorioretinopathy
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04511-y, 2019. [Link]
  23. Yuka Hasegawa, Yuki Hashimoto, Yasuhiro Shinmei and Susumu Ishida
    Optic nerve head microcirculation in congenital nasal optic disc hypoplasia
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04540-7, 2019. [Link]
  24. Wataru Saito, Yuki Hashimoto, Kiriko Hirooka and Susumu Ishida
    Changes in choroidal blood flow velocity in patients diagnosed with central serous chorioretinopathy during follow-up for pachychoroid pigment epitheliopathy
    American Journal of Ophthalmology Case Reports, doi:10.1016/j.ajoc.2020.100651, 2020. [Link]
  25. Mizuho Mitamura, Satoru Kase and Susumu Ishida
    Multimodal imaging in sclerochoroidal calcification: a case report and literature review
    BMC Ophthalmology, 20(1), 1-5, doi:10.1186/s12886-020-01520-y, 2020. [Link]
  26. Mizuho Mitamura, Satoru Kase, Kiriko Hirooka and Susumu Ishida
    Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect
    Oncotarget, 11(42), 3800-3804, doi:10.18632/oncotarget.27771, 2020. [Link]
  27. Yui Yamashita, Yuki Hashimoto, Kenichi Namba, Kazuomi Mizuuchi and Susumu Ishida
    Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
    Case Reports in Ophthalmology, 12, 899-908, doi:10.1159/000520036, 2021. [Link]
  28. Yui Yamashita, Michiyuki Saito, Kiriko Hirooka and Susumu Ishida
    Laser speckle flowgraphy findings in focal scleral nodule
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-021-05391-x, 2021. [Link]
  29. Kiriko Hirooka, Michiyuki Saito, Yui Yamashita, Yuki Hashimoto, Nobuhiro Terao, Hideki Koizumi, Kousuke Noda and Susumu Ishida
    Imbalanced choroidal circulation in eyes with asymmetric dilated vortex vein
    Japanese Journal of Ophthalmology, 66(1), 14-18, doi:10.1007/s10384-021-00889-7, 2021. [Link]
  30. Satoru Kase, Hiroaki Endo, Mitsuo Takahashi, Masahiko Yokoi, Yuki Ito, Satoshi Katsuta, Shozo Sonoda, Taiji Sakamoto, Susumu Ishida and Manabu Kase
    Involvements of choroidal vascular structures with local treatments in patients with diabetic macular edema
    European Journal of Ophthalmology, doi:10.1177/11206721211027103, 2021. [Link]
  31. Satoru Kase, Ayaka Hasegawa, Kiriko Hirooka, Hiroaki Endo, Kousuke Noda and Susumu Ishida
    Laser speckle flowgraphy findings in a patient with radiation retinopathy
    International Journal of Ophthalmology, 15(1), 172-174, doi:10.18240/ijo.2022.01.26, 2022. [Link]
  32. Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Hiroaki Endo, Yuki Ito, Yuko Cho and Susumu Ishida
    Alterations of choroidal circulation and vascular morphology in a patient with chronic myeloid leukemia before and after chemotherapy
    BMC Ophthalmology, 22(1), 1-7, doi:10.1186/s12886-022-02380-4, 2022. [Link]
  33. Tomoko Noda, Kousuke Noda, Kiriko Hirooka, Satoru Kase and Susumu Ishida
    Subretinal fluid accumulation in a patient with polycythemia vera after receiving a prostaglandin I2 analogue treatment
    American Journal of Ophthalmology Case Reports, doi:10.1016/j.ajoc.2022.101568, 2022. [Link]
  34. Risako Sone, Kousuke Noda, Kiriko Hirooka, Michiyuki Saito and Susumu Ishida
    Insidious progression of atrophic lesions in a case of posterior polar annular choroidal dystrophy
    American Journal of Ophthalmology Case Reports, 28, 101708, doi:10.1016/j.ajoc.2022.101708, 2022. [Link]
  35. Mizuho Mitamura, Satoru Kase, Kiriko Hirooka and Susumu Ishida
    A case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy
    BMC Ophthalmology, 23(1), 180, doi:10.1186/s12886-023-02933-1, 2023. [Link]
  36. Mizuho Mitamura, Satoru Kase, Kiriko Hirooka and Susumu Ishida
    Alterations of choroidal circulation and choroidal thickness before and after chemoradiotherapy in a case of metastatic choroidal tumor
    BMC Ophthalmology, 23(1), 270, doi:10.1186/s12886-023-03026-9, 2023. [Link]
  37. Mitamura Mizuho, Kase Satoru, Yamashita Yui, Hirooka Kiriko, Ishida Susumu
    Alterations in choroidal circulatory dynamics and choroidal thickness before and after treatment in posterior scleritis
    BMC Ophthalmol, 23(1), Sep 2023. doi:10.1186/s12886-023-03140-8 [Link]
  38. Kase Satoru, Yamashita Yui, Takeuchi Satoshi, Ishida Susumu
    Case Report: Laser speckle flowgraphy in a patient with uveitis due to immune-related adverse events by immune checkpoint inhibitors
    Front. Oncol., 15, May 2025. doi:10.3389/fonc.2025.1492011 [Link]
  39. Mitamura Mizuho, Kase Satoru, Nishiyama-Hirooka Kiriko, Saito Michiyuki, Ishida Susumu
    Two cases of juxtapapillary retinal astrocytic hamartoma: a multimodal imaging study
    BMC Ophthalmol, 25(1), Dec 2025. doi:10.1186/s12886-025-04516-8 [Link]

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Department of Ophthalmology, Sapporo Medical University

  1. H.Tagawa, H. Furukawa and H. Fujii
    Effect of topical timolol on the blood velocity of the iris microcirculation and the aqueous veins
    Invest Ophthalmol Vis. Sci. 1993, 34(Suppl): 927
  2. H.Tagawa, H. Furukawa and H. Fujii
    Dynamic Ocular Blood Flow Image Using Laser Speckle Flowgraphy
    Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995.
  3. Hiroshi Tagawa, Hideki Furukawa and Hitoshi Fujii
    Changes of Blood Circulation in Human Eyes with Retinal Diseases Using Real-Time Laser Flowgraphy
    Proc. 3rd Internet World Congress on Biomedical Sciences, 1996
  4. Tagawa H, Kawaguchi S,Furukawa H, and Fujii H.
    Effect of retrobulbar injection of unoprostone on the rabbit ocular microcirculation
    Invest Ophthalmol Vis Sci 1997, 38(Suppl): 782
  5. Kawaguchi S, Tagawa H, Maeda T, Suzuki J, and Fujii H.
    Circulatory changes of retinal vessels and choroidal microcirculation in eyes with arterial occlusive disease
    Invest Ophthalmol Vis Sci 1997, 38(Suppl): 1047
  6. Tagawa H, Nakagawa H,Furukawa H, and Fujii H.
    Visualization and quantitative evaluation of pulsatile ocular microcirculation by laser speckle flowgraphy
    Invest Ophthalmol Vis Sci 1998, 39(Suppl): 267
  7. Sasaki N, Tagawa H, Katsuta S, Nakagawa T andFujii H.
    Long term effects of oral prostaglandin on retinal artery, optic nerve head, and choroidal micricirculation in normals
    Invest Ophthalmol Vis Sci 1998, 39(Suppl): 271
  8. Tashimo A,Tagawa H, Kawaguchi S, Suzuki T, Nakagawa T and Fujii H.
    Effects of oral prostaglandin on retinal artery, optic nerve head, and choroidal micricirculation in eyes with arterial occlusive disease
    Invest Ophthalmol Vis Sci 1998, 39(Suppl): 999
  9. Katsuta S, Tagawa H, Suzuki T, Sasaki N, Nakagawa T and Fujii H.
    Short term effects of oral prostaglandin on retinal artery, optic nerve head, and choroidal micricirculation in normals
    Invest Ophthalmol Vis Sci 1998, 39(Suppl): 1000
  10. Tagawa H,Sasaki N,Tashimo A, Suzuki T, Shimizu M, Fujii H.
    Estimation of real blood velocity measured by laser speckle flowgraphy at retinal vessels
    Invest Ophthalmol Vis Sci 1999, 40(Suppl): 369
  11. Sasaki N, Tagawa H, Shimizu M, Suzuki T, Fujii H.
    Changes of pulsatility at retinal arteries as aging
    Invest Ophthalmol Vis Sci 1999, 40(Suppl): 488
  12. Katsuta S,Shimizu M, Tagawa H, Sasaki N, Suzuki T, Fujii H.
    Changes of pulsatility at choroidal microcirculation as aging
    Invest Ophthalmol Vis Sci 1999, 40(Suppl): 488
  13. Tashimo A, Tagawa H, Sasaki N, Suzuki T, Fujii H.
    Changes of pulsatility at retinal arteries and choroidal microcirculation in patients with arteriosclerosis
    Invest Ophthalmol Vis Sci 1999, 40(Suppl): 681
  14. Kimihito Maeda, Futoshi Ishikawa, Hiroshi Ohguro
    Ocular blood flow levels and visual prognosis in a patient with nonischemic type central retinal vein occlusion
    Clinical Ophthalmology 2009:3 489-491 doi:10.2147/opth.s6774 [Link]
  15. Ikuyo Ohguro, Hiroshi Ohguro
    The Effects of a Fixed Combination of 0.5% Timolol and 1% Dorzolamide on Optic Nerve Head Blood Circulation
    Journal of Ocular Pharmacology and Therapeutics (doi:10.1089/jop.2011.0243.), 2012. [Link]
  16. Hiroshi Ohguro, Ikuyo Ohguro, Maki Katai, Sachie Tanaka
    Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma
    Ophthalmologica(DOI: 10.1159/000335961), 2012. [Link]
  17. Fumihito Hikage, Masato Furuhashi, Yosuke Ida, Hiroshi Ohguro, Megumi Watanabe, Soma Suzuki and Kaku Itoh
    Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion
    PLOS ONE, 16(1), e0245763, doi:10.1371/journal.pone.0245763, 2021. [Link]
  18. Kaku Itoh, Masato Furuhashi, Yosuke Ida, Hiroshi Ohguro, Megumi Watanabe, Soma Suzuki and Fumihito Hikage
    Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy
    Scientific Reports, 11(1), 1-10, doi:10.1038/s41598-021-91857-1, 2021. [Link]

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Department of Cardiac Surgery, Asahikawa Medical University

  1. Fumiaki Kimura, Hirotsugu Kanda, Yuki Toyama, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida, Hiroto Kitahara and Hiroyuki Kamiya
    Evaluation of cerebral circulation during retrograde perfusion by laser speckle flowgraphy
    General Thoracic and Cardiovascular Surgery, doi:10.1007/s11748-016-0727-z, 2016.
  2. Hiroto Kitahara, Hirotsugu Kanda, Fumiaki Kimura, Tomohiro Takeda, Shingo Kunioka, Takayuki Kunisawa and Hiroyuki Kamiya
    Cerebral circulation estimated by laser speckle flowgraphy in retrograde femoral arterial perfusion during minimally invasive cardiac surgery.
    Interactive cardiovascular and thoracic surgery, 25(1), 25-29, doi:10.1093/icvts/ivx046, 2017. [Link]
  3. Istaphanous George, Wong Christine, Abd-Elsayed Alaa
    Improving Efficiency in the Cardiac Catheterization Laboratory
    Journal of Cardiothoracic and Vascular Anesthesia, 31(4), e66-e67, Aug 2017. doi:10.1053/j.jvca.2017.02.185 [Link]
  4. Kikuchi Shinsuke, Miyake Keisuke, Tada Yuki, Uchida Daiki, Koya Atsuhiro, Saito Yukihiro, Ohura Takehiko, Azuma Nobuyoshi
    Laser speckle flowgraphy can also be used to show dynamic changes in the blood flow of the skin of the foot after surgical revascularization
    Vascular, 27(3), 242-251, Jun 2019. doi:10.1177/1708538118810664 [Link]
  5. Yokota Harumasa, Hayashi Hiroki, Nakagami Hironori, Kushiyama Akifumi, Hanaguri Junya, Honjo Megumi, Aihara Makoto, Kurano Makoto, Igarashi Koji, Kushiyam Sakura, Yamagami Satoru, Nagaoka Taiji
    Evidence Supporting Autotaxin as a Potential New Drug Treatment Target in Patients With Advanced Diabetic Retinopathy
    Invest. Ophthalmol. Vis. Sci., 66(15), 49, Dec 2025. doi:10.1167/iovs.66.15.49 [Link]

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Department of Anesthesiology and Critical care, Asahikawa Medical University

  1. Hirotsugu Kanda, Fumiaki Kimura, Takafumi Iida, Megumi Kanao-Kanda, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida and Hiroyuki Kamiya
    Combined Use of Intra-aortic Balloon Pump and Venoarterial Extracorporeal Membrane Oxygenation Support With Femoral Arterial Cannulation Impairs Cerebral Microcirculation: Evaluation With Laser Speckle Flowgraphy
    Journal of Cardiothoracic and Vascular Anesthesia, doi:10.1053/j.jvca.2016.09.012, 2016.
  2. Hirotsugu Kanda, Hiroto Kitahara, Yuki Toyama, Megumi Kanao-Kanda, Takayuki Kunisawa and Hiroyuki Kamiya
    Intra-aortic Balloon Pump Does Not Impede Cerebral Microcirculation During Central Extracorporeal Membrane Oxygenation Support: Evaluation With Laser Speckle Flowgraphy
    Journal of Cardiothoracic and Vascular Anesthesia, 31(4), e67-e68, doi:10.1053/j.jvca.2017.04.030, 2017. [Link]
  3. Hirotsugu Kanda, TakayukiKunisawa, Hiroto Kitahara, Takafumi Iida, Yuki Toyama, Megumi Kanao-Kanda, Chie Mori and Hiroyuki Kamiya
    Cerebral Hypoxia Caused by Flow Confliction During Minimally Invasive Cardiac Surgery With Retrograde Perfusion: A Word of Caution
    Journal of Cardiothoracic and Vascular Anesthesia, 32(4), 1838-1840, doi:10.1053/j.jvca.2017.10.007, 2017. [Link]
  4. Hirotsugu Kanda, Takayuki Kunisawa, Takafumi Iida, Masahiro Tada, Fumiaki Kimura, Hayato Ise and Hiroyuki Kamiya
    Cerebral circulation during retrograde cerebral perfusion: evaluation using laser speckle flowgraphy
    The Annals of Thoracic Surgery, doi:10.1016/j.athoracsur.2018.11.067, 2018. [Link]
  5. Megumi Kanao-Kanda, Hirotsugu Kanda, Takafumi Iida, Shinsuke Kikuchi and Nobuyoshi Azuma
    Clinical Application of Laser Speckle Flowgraphy to Assess Changes in Blood Flow to the Foot After a Lumbar Sympathetic Ganglion Block: A Case Report
    Journal of Pain Research, 14, 1451-1456, doi:10.2147/JPR.S305543, 2021. [Link]

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Department of Ophthalmology, Tohoku University

  1. Elbatarny Ashraf
    Combined intravitreal bevacizumab and photodynamic therapy with vertiporfin for management of choroidal neovascularization secondary to age-related macular degeneration
    OPTH, Mar 2008. doi:10.2147/OPTH.S2320 [Link]
  2. Yu Yokoyama, Naoko Aizawa, Naoki Chiba, Kazuko Omodaka, Masahiko Nakamura, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa
    Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk
    Clinical Ophthalmology, 2011:5, 1721 - 1727 doi:10.2147/opth.s23204 [Link]
  3. Naoki Chiba, Kazuko Omodaka, Yu Yokoyama, Naoko Aizawa, Satoru Tsuda, Masayuki Yasuda, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa
    Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
    Clinical Ophthalmology, 2011:5, 1549-1556 doi:10.2147/opth.s22097 [Link]
  4. Naoko Aizawa, Yu Yokoyama, Naoki Chiba, Kazuko Omodaka, Masayuki Yasuda, Takaaki Otomo, Masahiko Nakamura, Nobuo Fuse, Toru Nakazawa
    Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
    Clinical Ophthalmology, 2011:5, 1171-1176 doi:10.2147/OPTH.S22093 [Link]
  5. Yukihiro Shiga, Masahiko Shimura, Toshifumi Asano, Satoru Tsuda, Yu Yokoyama, Naoko Aizawa,
    Kazuko Omodaka, Morin Ryu, Shunji Yokokura, Takayuki Takeshita and Toru Nakazawa
    The Influence of Posture Change on Ocular Blood Flow in Normal Subjects, Measured by Laser Speckle Flowgraphy
    Current Eye Research, June 2013, Vol. 38, No. 6 , Pages 691-698 (doi:10.3109/02713683.2012.758292) [Link]
  6. Tsuda, Satoru MD; Yokoyama, Yu MD; Chiba, Naoki MD; Aizawa, Naoko MD; Shiga, Yukihiro MD; Yasuda, Masayuki MD; Yokokura, Shunji PhD, MD; Otomo, Takaaki MD; Fuse, Nobuo PhD, MD; Nakazawa, Toru PhD, MD
    Effect of Topical Tafluprost on Optic Nerve Head Blood Flow in Patients With Myopic Disc Type
    Journal of Glaucoma, POST AUTHOR CORRECTIONS, 2 April 2013, doi: 10.1097/IJG.0b013e318237c8b3 [Link]
  7. Naoko Aizawa, Hiroshi Kunikata, Yu Yokoyama and Toru Nakazawa
    Correlation between optic disc microcirculation in glaucoma measured with laser speckle flowgraphy and fluorescein angiography, and the correlation with mean deviation
    Clinical and experimental ophthalmology, 42(3), 293-294, doi:10.1111/ceo.12130, 2013. [Link]
  8. Yukihiro Shiga, Kazuko Omodaka, Hiroshi Kunikata, Morin Ryu, Yu Yokoyama, Satoru Tsuda, Toshifumi Asano, Shigeto Maekawa, Kazuichi Maruyama, Toru Nakazawa
    Waveform analysis of ocular blood flow and the early detection of normal-tension glaucoma
    IOVS, October 15, 2013 IOVS-13-12930(doi:10.1167/iovs.13-12930) [Link]
  9. Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Noriko Himori and Toru Nakazawa
    Factors Associated With Visual Acuity Decline in Glaucoma Patients With Loss of Ganglion Cell Complex Thickness
    Translational Vision Science and Technology, 12(7), 2, doi:10.1167/tvst.12.7.2, 2013. [Link]
  10. Shin Takayama, Yukihiro Shiga, Taiki Kokubun, Hideyuki Konno, Noriko Himori, Morin Ryu, Takehiro Numata, Soichiro Kaneko, Hitoshi Kuroda, Junichi Tanaka, Seiki Kanemura, Tadashi Ishii, Nobuo Yaegashi, Toru Nakazawa
    The traditional kampo medicine tokishakuyakusan increases ocular blood flow in healthy subjects
    Evidence-Based Complementary and Alternative Medicine, 2014. doi:10.1155/2014/586857 [Link]
  11. Satoru Tsuda, Hiroshi Kunikata, Masahiko Shimura, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Yu Yokoyama, Toru Nakazawa
    Pulse-Waveform Analysis of Normal Population using Laser Speckle Flowgraphy
    Current Eye Research, Posted online on April 21, 2014. (doi:10.3109/02713683.2014.905608) [Link]
  12. Yukihiro Shiga, Toshifumi Asano, Hiroshi Kunikata, Fumihiko Nitta, Hajime Sato, Toru Nakazawa and Masahiko Shimura
    Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy
    Investigative Ophthalmology & Visual Science, IOVS-14, 2014. (doi: 10.1167/iovs.14-14116) [Link]
  13. Shunsuke Omodaka, Hidenori Endo, Hiroshi Doi, Hiroaki Shimizu, Miki Fujimura, Naoko Aizawa, Toru Nakazawa and Teiji Tominaga
    Usefulness of Laser Speckle Flowgraphy for the Assessment of Ocular Blood Flow in Extracranial Intracranial Bypass
    Journal of Stroke and Cerebrovascular Diseases (2014). doi:10.1016/j.jstrokecerebrovasdis.2014.06.021 [Link]
  14. Naoko Aizawa, Fumihiko Nitta, Hiroshi Kunikata, Tetsuya Sugiyama, Tsunehiko Ikeda, Makoto Araie and Toru Nakazawa
    Laser speckle and hydrogen gas clearance measurements of optic nerve circulation in albino and pigmented rabbits with or without optic disc atrophy.
    Investigative Ophthalmology & Visual Science, IOVS-14, 2014. doi: 10.1167/iovs.14-15373 [Link]
  15. Wataru Kobayashi, Hiroshi Kunikata, Kazuko Omodaka, Kyousuke Togashi, Morin Ryu, Masahiro Akiba, Gaku Takeuchi, Tetsuya Yuasa, and Toru Nakazawa
    Correlation of Optic Nerve Microcirculation with Papillomacular Bundle Structure in Treatment Naive Normal Tension Glaucoma
    Journal of Ophthalmology, vol. 2014, Article ID 468908, 9 pages, 2014. doi:10.1155/2014/468908 [Link]
  16. Fumihiko Nitta, Hiroshi Kunikata, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda and Toru Nakazawa
    The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy
    Clinical Ophthalmology, 2014:8, 1119 - 1127 doi:10.2147/OPTH.S62022 [Link]
  17. Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Yu Yokoyama, Kazuko Omodaka and Toru Nakazawa
    Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser speckle flowgraphy.
    BMC Ophthalmology, 14(1), 113. doi:10.1186/1471-2415-14-113 [Link]
  18. Shiga Yukihiro, Sato Marika, Maruyama Kazuichi, Takayama Shin, Omodaka Kazuko, Himori Noriko, Kunikata Hiroshi, Nakazawa Toru
    Assessment of Short-Term Changes in Optic Nerve Head Hemodynamics in Hyperoxic Conditions with Laser Speckle Flowgraphy
    Current Eye Research, 40(10), 1055-1062, Oct 2015. doi:10.3109/02713683.2014.971934 [Link]
  19. Hiroshi Kunikata, Naoko Aizawa, Masataka Kudo, Shunji Mugikura, Fumihiko Nitta, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Fumitoshi Satoh, Hidetoshi Takahashi, Sadayoshi Ito, Shoki Takahashi and Toru Nakazawa
    Relationship of Ocular Microcirculation, Measured by Laser Speckle Flowgraphy, and Silent Brain Infarction in Primary Aldosteronism
    PLOS ONE, 10(2), e0117452, 2015. doi:10.1371/journal.pone.0117452 [Link]
  20. Noriko Himori, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Hidetoshi Takahashi and Toru Nakazawa
    The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma
    Graefe's Archive for Clinical and Experimental Ophthalmology, 1-9, 2015. doi:10.1007/s00417-015-3203-z [Link]
  21. Hiroshi Kunikata, Toru Nakazawa
    Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease.
    The Asia-Pacific Journal of Ophthalmology, 2015 doi:10.1097/apo.0000000000000160 [Link]
  22. Aizawa Naoko, Kunikata Hiroshi, Nitta Fumihiko, Nakazawa Toru
    The relationship between laser speckle flowgraphy‐measured optic disc microcirculation and postoperative visual recovery in rhegmatogenous retinal detachment
    Acta Ophthalmologica, 93(5), Aug 2015. doi:10.1111/aos.12586 [Link]
  23. Kiyota Naoki, Shiga Yukihiro, Takahashi Hidetoshi, Nakazawa Toru
    Large vessel area of the optic nerve head, measured with laser speckle flowgraphy, is significantly reduced in eyes with preperimetric glaucoma
    Clinical Exper Ophthalmology, 43(9), 841-843, Dec 2015. doi:10.1111/ceo.12562 [Link]
  24. Yukihiro Shiga, Hiroshi Kunikata, Naoko Aizawa, Naoki Kiyota, Yukiko Maiya, Yu Yokoyama, Kazuko Omodaka, Hidetoshi Takahashi, Tomoki Yasui, Keiichi Kato, Aiko Iwase and Toru Nakazawa
    Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma
    Current Eye Research, doi:10.3109/02713683.2015.1127974, 2016. [Link]
  25. Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Yukihiro Shiga, Kazuko Omodaka, Satoru Tsuda and Toru Nakazawa
    Age-and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation.
    PLOS ONE, 11(2), e0148812, 2016.
  26. Toru Nakazawa
    Ocular Blood Flow and Influencing Factors for Glaucoma.
    The Asia-Pacific Journal of Ophthalmology, 5(1), 38-44, 2016. doi:10.1097/APO.0000000000000183 [Link]
  27. Maki Inoue, Noriko Himori, Hiroshi Kunikata, Takayuki Takeshita, Naoko Aizawa, Yukihiro Shiga,Kazuko Omodaka, Koji M Nishiguchi, Hidetoshi Takahashi and Toru Nakazawa
    The reduction of temporal optic nerve head microcirculation in autosomal dominant optic atrophy
    Acta ophthalmologica, 94(7), e580-e585, doi:10.1111/aos.12999, 2016. [Link]
  28. Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Tsutomu Kikawa, Noriko Himori, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Akiba and Toru Nakazawa
    Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography
    PLOS ONE, 11(4), e0153707, 2016. doi:10.1371/journal.pone.0153707 [Link]
  29. Kazuki Hashimoto, Hiroshi Kunikata, Masayuki Yasuda, Azusa Ito, Naoko Aizawa, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Yoshimasa Takano, Koji M. Nishiguchi, Hideki Katagiri and Toru Nakazawa
    The relationship between advanced glycation end products and ocular circulation in type 2 diabetes
    Journal of Diabetes and its Complications, 2016. doi:10.1016/j.jdiacomp.2016.04.024 [Link]
  30. Aizawa Naoko, Kunikata Hiroshi, Nitta Fumihiko, Shiga Yukihiro, Omodaka Kazuko, Tsuda Satoru, Nakazawa Toru
    Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation
    PLoS ONE, 11(2), e0148812, Feb 2016. doi:10.1371/journal.pone.0148812 [Link]
  31. Kazuko Omodaka, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba and Toru Nakazawa
    Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters
    PloS one, 12(12), e0190012, doi:10.1371/journal.pone.0190012, 2017. [Link]
  32. Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
    Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-017-3627-8, 1-10, 2017. [Link]
  33. Naoki Kiyota, Yukihiro Shiga, Shiori Suzuki, Marika Sato, Naoko Takada, Shigeto Maekawa, Kazuko Omodaka, Kazuichi Maruyama, Hiroshi Kunikata and Toru Nakazawa
    The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Primary Open-Angle Glaucoma Patients
    Investigative Ophthalmology and Visual Science, 58(7), 3181-3188, doi: 10.1167/iovs.17-21648, 2017. [Link]
  34. Kazuichi Maruyama, Aya Noguchi, Ai Shimizu, Yukihiro Shiga, Hiroshi Kunikata and Toru Nakazawa
    Predictors of Recurrence in Vogt-Koyanagi-Harada Disease
    Ophthalmology Retina, doi: 10.1016/j.oret.2017.07.016, 2017. [Link]
  35. Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
    Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal-tension glaucoma with myopic disc
    Acta Ophthalmologica, doi:10.1111/aos.13621, 2017. [Link]
  36. Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto and Toru Nakazawa
    Preperimetric Glaucoma Prospective Observational Study (PPGPS): Design, baseline characteristics, and therapeutic effect of tafluprost in preperimetric glaucoma eye
    PLOS ONE, 12(12), e0188692, doi:10.1371/journal.pone.0188692, 2017. [Link]
  37. Yukihiro Shiga, Koji M. Nishiguchi, Yosuke Kawai, Kaname Kojima, Kota Sato, Kosuke Fujita, Mai Takahashi, Kazuko Omodaka, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Nobuo Fuse, Masayuki Yamamoto, Jun Yasuda, Masao Nagasaki, Toru Nakazawa , for the Japan Glaucoma Society Omics Group (JGS-OG)
    Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7.
    PloS one, 12(12), e0186678, doi:10.1371/journal.pone.0186678, 2017. [Link]
  38. Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Hiroshi Kunikata, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto and Toru Nakazawa
    Preperimetric Glaucoma Prospective Study (PPGPS): Predicting Visual Field Progression With Basal Optic Nerve Head Blood Flow in Normotensive PPG Eyes
    Translational vision science and technology, 7(1), 11, doi:10.1167/tvst.7.1.11, 2018. [Link]
  39. Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
    Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma.
    Acta Ophthalmologica, doi:10.1111/aos.13639, 2018. [Link]
  40. Naoki Kiyota, Yukihiro Shiga, Kohei Ichinohasama, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Naoto Honda, Hiroshi Kunikata and Toru Nakazawa
    The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow
    Investigative Ophthalmology & Visual Science, 59(8), 3488-3496, 2018. doi:10.1167/iovs.18-23872 [Link]
  41. Maki Inoue-Yanagimachi, Noriko Himori, Kota Sato, Taiki Kokubun, Toshifumi Asano, Yukihiro Shiga, Satoru Tsuda, Hiroshi Kunikata and Toru Nakazawa
    Association between mitochondrial DNA damage and ocular blood flow in patients with glaucoma
    British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2018-312356, 2018. [Link]
  42. An Guangzhou, Omodaka Kazuko, Tsuda Satoru, Shiga Yukihiro, Takada Naoko, Kikawa Tsutomu, Nakazawa Toru, Yokota Hideo, Akiba Masahiro
    Comparison of Machine-Learning Classification Models for Glaucoma Management
    Journal of Healthcare Engineering, 2018, 1-8, Jun 2018. doi:10.1155/2018/6874765 [Link]
  43. Kohei Ichinohasama, Hiroshi Kunikata, Azusa Ito, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Hideki Katagiri and Toru Nakazawa
    The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes
    Journal of Ophthalmology, doi:10.1155/2019/3421305, 2019. [Link]
  44. Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata and Toru Nakazawa
    Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression
    Investigative Ophthalmology & Visual Science, 60(7), 2650-2658, doi:10.1167/iovs.19-27230, 2019. [Link]
  45. Toru Nakazawa, Takeo Fukuchi
    What is glaucomatous optic neuropathy?
    Japanese Journal of Ophthalmology, 64(3), 243–249, doi:10.1007/s10384-020-00736-1, 2020. [Link]
  46. Toshifumi Asano, Hiroshi Kunikata, Masayuki Yasuda, Koji M. Nishiguchi, Toshiaki Abe and Toru Nakazawa
    Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab
    International Ophthalmology, doi:10.1007/s10792-020-01562-7, 2020. [Link]
  47. Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Kyongsun Pak and Toru Nakazawa
    Time-course Changes in Optic Nerve Head Blood Flow and Retinal Nerve Fiber Layer Thickness in Eyes with Open-angle Glaucoma
    Ophthalmology, doi:10.1016/j.ophtha.2020.10.010, 2020. [Link]
  48. Masayuki Yasuda, Hajime Sato, Kazuki Hashimoto, Urara Osada, Takehiro Hariya, Hiroko Nakayama, Toshifumi Asano, Noriyuki Suzuki, Tatsu Okabe, Mai Yamazaki, Megumi Uematsu, Masanori Munakata and Toru Nakazawa
    Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion
    PloS one, 15(10), e0240977, doi:10.1371/journal.pone.0240977, 2020. [Link]
  49. Nana Takahashi, Hiroshi Kunikata, Masayuki Yasuda, Takehiro Hariya, Koji M. Nishiguchi and Toru Nakazawa
    Polypoidal choroidal vasculopathy in a case of retinitis pigmentosa, successfully treated with intravitreal aflibercept
    American Journal of Ophthalmology Case Reports, 101123, doi:10.1016/j.ajoc.2021.101123, 2021. [Link]
  50. Chiaki Yamaguchi, Hiroshi Kunikata, Kazuki Hashimoto, Masaaki Yoshida, Takahiro Ninomiya, Takehiro Hariya, Toshiaki Abe and Toru Nakazawa
    De novo Vogt-Koyanagi-Harada disease after vaccination for COVID-19, successfully treated with systemic steroid therapy and monitored with laser speckle flowgraphy
    American Journal of Ophthalmology Case Reports, 101616, doi:10.1016/j.ajoc.2022.101616, 2022. [Link]
  51. Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
    The relationship between choroidal blood flow and glaucoma progression in a Japanese study population
    Japanese Journal of Ophthalmology, doi:10.1007/s10384-022-00929-w, 2022. [Link]
  52. Nana Takahashi, Naoki Kiyota, Hiroshi Kunikata, Mai Yamazaki, Takayuki Nishimura, Yukihiro Shiga, Hisae Aoyagi, Miwako Shidomi, Tomohiro Tsuda, Toshihiko Ohtsuka, Takahiro Tomida and Toru Nakazawa
    Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients
    BMC Ophthalmology, 23(1), 1-11, doi:10.1186/s12886-023-03059-0, 2023. [Link]
  53. Takahashi Nana, Sato Kota, Kiyota Naoki, Tsuda Satoru, Murayama Namie, Nakazawa Toru
    A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction
    Sci Rep, 13(1), Dec 2023. doi:10.1038/s41598-023-49598-w [Link]
  54. Masataka Sato, Masayuki Yasuda, Nana Takahashi, Kazuki Hashimoto, Noriko Himori and Toru Nakazawa
    Sex differences in the association between systemic oxidative stress status and optic nerve head blood flow in normal-tension glaucoma
    PLOS ONE, 18(2), e0282047, doi:10.1371/journal.pone.0282047, 2023. [Link]
  55. Kiyota Naoki, Shiga Yukihiro, Ninomiya Takahiro, Tsuda Satoru, Omodaka Kazuko, Himori Noriko, Yokoyama Yu, Pak Kyongsun, Nakazawa Toru
    The Effect of β-Blocker Eye Drops on Pulse Rate, Ocular Blood Flow, and Glaucoma Progression: A Retrospective Longitudinal Study
    Adv Ther, 41(2), 730-743, Feb 2024. doi:10.1007/s12325-023-02762-0 [Link]
  56. Takahashi Naoki, Omodaka Kazuko, Kikawa Tsutomu, Ninomiya Takahiro, Kiyota Naoki, Tsuda Satoru, Nakazawa Toru
    Comparative features of superior versus inferior hemisphere microvasculature dropout in open-angle glaucoma
    Jpn J Ophthalmol, 68(4), 311-320, Jul 2024. doi:10.1007/s10384-024-01071-5 [Link]
  57. Yamamoto Nobuhiko, Nakano Makoto, Nochioka Kotaro, Yasuda Masayuki, Kunikata Hiroshi, Nakazawa Toru, Yasuda Satoshi
    Ocular blood flow dynamics following sinus rhythm restoration through catheter ablation: laser speckle flowgraphy in patients with persistent atrial fibrillation
    European Heart Journal - Imaging Methods and Practice, 2(3), Jul 2024. doi:10.1093/ehjimp/qyae071 [Link]
  58. Yamaguchi Chiaki, Kiyota Naoki, Himori Noriko, Misu Tatsuro, Kaneko Kimihiko, Otomo Mizuki, Takagi Airi, Oshima Takahiro, Kimura Ryo, Omodaka Kazuko, Tsuda Satoru, Aoki Masashi, Nakazawa Toru
    Differentiation of acute-phase AQP4-IgG+ optic neuritis from CNS inflammatory diseases using optic nerve head blood flow analysis
    Sci Rep, 15(1), Sep 2025. doi:10.1038/s41598-025-19110-7 [Link]
  59. Shi Ge, Sato Kota, Takahashi Nana, Ohno-Ohishi Michiko, Murayama Namie, Yamaguchi Chiaki, Saigusa Daisuke, Nakazawa Toru
    AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal ganglion cell loss in rats
    Life Sci. Alliance, 8(8), e202403087, Aug 2025. doi:10.26508/lsa.202403087 [Link]
  60. Takahashi Nana, Shiga Yukihiro, Kiyota Naoki, Yasuda Masayuki, Takahashi Naoki, Sato Kota, Arita Ryutaro, Kikuchi Akiko, Takayama Shin, Ishii Tadashi, Nakazawa Toru
    Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition
    Trans. Vis. Sci. Tech., 14(4), 9, Apr 2025. doi:10.1167/tvst.14.4.9 [Link]
  61. Yamaguchi Chiaki, Kiyota Naoki, Himori Noriko, Oshima Takahiro, Takeshita Takayuki, Omodaka Kazuko, Tsuda Satoru, Nakazawa Toru
    Evaluation of blood flow in arteritic anterior ischemic optic neuropathy using laser speckle flowgraphy: A case series
    American Journal of Ophthalmology Case Reports, 38, 102316, Jun 2025. doi:10.1016/j.ajoc.2025.102316 [Link]
  62. Yamaguchi Chiaki, Kiyota Naoki, Himori Noriko, Omodaka Kazuko, Tsuda Satoru, Nakazawa Toru
    Differentiating optic neuropathies using laser speckle flowgraphy: Evaluating blood flow patterns in the optic nerve head and peripapillary choroid
    Acta Ophthalmologica, 103(1), Feb 2025. doi:10.1111/aos.16747 [Link]
  63. Hanyuda Akiko, Tsuda Satoru, Takahashi Nana, Takahashi Naoki, Sato Kota, Nakazawa Toru
    Effects of a Red-Ginger-Based Multi-Nutrient Supplement on Optic Nerve Head Blood Flow in Open-Angle Glaucoma
    Nutrients, 18(1), 140, Jan 2026. doi:10.3390/nu18010140 [Link]
  64. Yamamoto Nobuhiko, Suzuki Hideaki, Nakano Makoto, Yamanaka Shinich, Ito Tomohiro, Sato Hiroyuki, Chiba Takahiko, Nochioka Kotaro, Takanami Kentaro, Yasuda Masayuki, Kunikata Hiroshi, Nakazawa Toru, Yasuda Satoshi
    Linking the heart–eye–brain axis: Ocular and cerebral blood flow changes after catheter ablation in atrial fibrillation
    Heart Rhythm, Feb 2026. doi:10.1016/j.hrthm.2026.02.003 [Link]

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Department of Obstetrics and Gynecology, Tohoku University

  1. Takahiro Sato, Junichi Sugawara , Naoko Aizawa, Noriyuki Iwama, Fumiaki Takahashi, Michiyo Nakamura-Kurakata, Masatoshi Saito, Takashi Sugiyama, Hiroshi Kunikata, Toru Nakazawa and Nobuo Yaegashi
    Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy
    PLOS ONE, 12(3), e0173127, doi:10.1371/journal.pone.0173127, 2017. [Link]

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Department of Ophthalmology, Akita University

  1. Yusuke Ohta, Sanae Takaseki and Takeshi Yoshitomi
    Effects of ripasudil hydrochloride hydrate (K-115), a Rho-kinase inhibitor, on ocular blood flow and ciliary artery smooth muscle contraction in rabbits
    Japanese journal of ophthalmology, 61(5), 423–432, 2017. doi:10.1007/s10384-017-0524-y [Link]
  2. Ya-Ru Dong, Shi-Wei Huang, Ji-Zhe Cui and Takeshi Yoshitomi
    Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo
    International Journal of Ophthalmology, 11(5), 719–725, 2018. doi:10.18240/ijo.2018.05.03 [Link]
  3. Takeshi Iwase, Yoshitaka Ueno, Ryo Tomita and Hiroko Terasaki
    Relationship Between Retinal Microcirculation and Renal Function in Patients with Diabetes and Chronic Kidney Disease by Laser Speckle Flowgraphy
    Life, 13(2), 424, doi:10.3390/life13020424, 2023. [Link]

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Department of Ophthalmology, Gunma University

  1. Hiroaki Isono, Shoji Kishi, Yasutaka Kimura, Naoya Hagiwara, Naoki Konishi and Hitoshi Fujii
    Observation of Choroidal Circulation Using Index of Erythrocytic Velocity
    Arch Ophthalmol, 121, no.2, 225-231, 2003. doi:10.1001/archopht.121.2.225 [Link]
  2. A. Otsubo, S. Kishi, K. Ohkoshi and T. Ymaguchi
    The Influence of Peripheral Retinal Detachment in Choroidal Blood Flow of the Macula
    ARVO, 2003, (3004/B843)
  3. Watanabe G, Fujii H, Kishi S
    Imaging of Choroidal Hemodynamics in Eyes with Polypoidal Choroidal Vasculopathy Using Laser Speckle Phenomenon
    Jpn J Ophthalmol 52: 204-210, 2008 doi:10.1007/s10384-007-0521-7 [Link]
  4. Yoichiro Shinohara, Tomoyuki Kashima, Hideo Akiyama, Shoji Kishi
    Alteration of choroidal thickness in a case of carotid cavernous fistula: a case report and a review of the literature
    BMC Ophthalmology 2013, 13:75 doi:10.1186/1471-2415-13-75 [Link]
  5. Yoichiro Shinohara, Tomoyuki Kashima, Hideo Akiyama, Yukitoshi Shimoda, Danjie Li and Shoji Kishi
    Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy
    PLOS ONE, 12(1), e0169596, 2017. doi:10.1371/journal.pone.0169596 [Link]

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Department of Neurosurgery, Saitama Medical Center, Saitama Medical University

  1. Shinsuke Yoshida, Soichi Oya, Hiroto Obata, Naoaki Fujisawa, Tsukasa Tsuchiya, Takumi Nakamura, Masahiro Indo, Masaaki Shojima and Toru Matsui
    Carotid endarterectomy restores decreased vision due to chronic ocular ischemia
    Acta Neurochir, doi:10.1007/s00701-020-04603-3, 2020. [Link]

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Department of Ophthalmology, Niigata University

  1. Kiyoshi Yaoeda, Motohiro Shirakashi, Shigeo Funaki, Haruko Funaki, Tomoko Nakatsue, Atsushi Fukushima
    Measurement of Microcirculation in the Optic Nerve Head by Laser Speckle Flowgraphy and Scanning Laser Doppler Flowmetry.
    Am. J. Ophthalmol., 129, NO. 6, 734-739, 2000. doi:10.1016/s0002-9394(00)00382-2 [Link]
  2. Kiyoshi Yaoeda, Motohiro Shirakashi, Shigeo Funaki, Haruko Funaki, Tomoko Nakatsue, Atsushi Fukushima AND Haruki Abe
    Measurement of Microcirculation in Optic Nerve Head by Laser Speckle Flowgraphy in Normal Volunteers
    Am. J. Ophthalmol., 130, NO. 5, 606-610, 2000. doi:10.1016/s0002-9394(00)00723-6 [Link]
  3. Kiyoshi Yaoeda, Motohiro Shirakashi, Atsushi Fukushima, Shigeo Funaki, Haruko Funaki, Haruki Abe and Naohito Tanabe
    Relationship between optic nerve head microcirculation and visual field loss in glaucoma.
    Acta Ophthalmol. Scand, 81, 253-259, 2003. doi:10.1034/j.1600-0420.2003.00073.x [Link]

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Department of Ophthalmology, University of Toyama

  1. Yuta Takata, Yasuhito Nitta, Akio Miyakoshi and Atsushi Hayashi
    Retinal Endovascular Surgery with Tissue Plasminogen Activator Injection for Central Retinal Artery Occlusion
    Case Reports in Ophthalmology, 9(2), 327-332, doi:10.1159/000489696, 2018. [Link]
  2. Shinya Abe, Tomoko Nakamura, Erika Okumura, Toshihiko Oiwake, Annabelle A. Okada and Atsushi Hayashi
    Long-term changes of choroidal blood flow velocity in Vogt-Koyanagi-Harada disease
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-021-05540-2, 2022. [Link]

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Department of Ophthalmology, Toho University Sakura Medical Center

  1. Tomoaki Shiba, Mao Takahashi, Yuichi Hori and Takatoshi Maeno
    Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachialankle pulse-wave velocity, carotid intima media thickness, and age
    Graefe's Archive for Clinical and Experimental Ophthalmology (DOI: 10.1007/s00417-012-1952-5), 2012. [Link]
  2. Shiba T, Takahashi M, Hori Y, Maeno T, Shirai K.
    Optic Nerve Head Circulation Determined by Pulse Wave Analysis is Significantly Correlated with Cardio Ankle Vascular Index, Left Ventricular Diastolic Function, and Age.
    Journal of atherosclerosis and thrombosis, Published online: July 4, 2012. doi:10.5551/jat.13631 [Link]
  3. Tomoaki Shiba, Mao Takahashi, Takatoshi Maeno
    Pulse-Wave Analysis of Optic Nerve Head Circulation Is Significantly Correlated With Kidney Function in Patients With and Without Chronic Kidney Disease
    Journal of Ophthalmology, 2013. doi:10.1155/2014/291687 [Link]
  4. Makoto Ubuka, Tetsuya Sugiyama, Yasutaka Onoda, Tomoaki Shiba, Yuichi Hori, Takatoshi Maeno
    Changes in the Blood Flow of the Optic Nerve Head Induced by Different Concentrations of Epinephrine in Intravitreal Infusion During Vitreous Surgery
    Investigative Ophthalmology & Visual Science, 2014, IOVS-13-13801. doi:10.1167/iovs.13-13801 [Link]
  5. Muramatsu Rina, Tomoaki Shiba, Mao Takahashi, Yuichi Hori and Takatoshi Maeno
    Pulse waveform analysis of optic nerve head circulation for predicting carotid atherosclerotic changes.
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-015-3123-y, 2015. [Link]
  6. Ryuya Hashimoto, Asato Hirota and Takatoshi Maeno
    Choroidal blood flow impairment demonstrated using laser speckle flowgraphy in a case of commotio retinae
    American Journal of Ophthalmology Case Reports, doi: 10.1016/j.ajoc.2016.08.002, 2016. [Link]
  7. Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka and Takatoshi Maeno
    Autoregulation of Optic Nerve Head Blood Flow Induced by Elevated Intraocular Pressure during Vitreous Surgery.
    Current Eye Research, doi: 10.1080/02713683.2016.1220592, 2016. [Link]
  8. Ryuya Hashimoto, Tetsuya Sugiyama, Hidetaka Masahara, Masashi Sakamoto, Makoto Ubuka and Takatoshi Maeno
    Impaired Autoregulation of Blood Flow at the Optic Nerve Head during Vitrectomy in Patients with Type 2 Diabetes
    American Journal of Ophthalmology, doi: 10.1016/j.ajo.2017.06.021, 2017. [Link]
  9. Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka and Takatoshi Maeno
    Impairment of autoregulation of optic nerve head blood flow during vitreous surgery in patients with hypertension and hyperlipidemia
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-017-3788-5, 2017. [Link]
  10. Ryuya Hashimoto, Juri Kawamura, Asato Hirota, Mizuho Oyamada, Asao Sakai and Takatoshi Maeno
    Changes in choroidal blood flow and choroidal thickness after treatment in two cases of pediatric anisohypermetropic amblyopia
    American Journal of Ophthalmology Case Reports, Volume 8, 39-43, doi: 10.1016/j.ajoc.2017.10.010, 2017. [Link]
  11. Ryuya Hashimoto, Tetsuya Sugiyama and Takatoshi Maeno
    Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy
    BioMed Research International, vol. 2017, Article ID 6041590, 6 pages, doi:10.1155/2017/6041590, 2017. [Link]
  12. Ryuya Hashimoto, Mizuho Oyamada and Takatoshi Maeno
    Analysis of Optic Nerve Head Circulation Using Laser Speckle Flowgraphy in a Case of Pediatric Optic Neuritis
    EC Ophthalmology, 9(8), 572-581, 2018.
  13. Ryo Yamazaki, Ryuya Hashimoto, Hidetaka Masahara, Masashi Sakamoto and Takatoshi Maeno
    Time Course in Ocular Blood Flow and Pulse Waveform in a Case of Ocular Ischemic Syndrome with Intraocular Pressure Fluctuation
    Vision, 4(2), 31, doi:10.3390/vision4020031, 2020. [Link]
  14. Keisuke Yata, Ryuya Hashimoto, Hidetaka Masahara, Mizuho Oyamada and TakatoshiMaeno
    Changes in choroidal circulation and pulse waveform in a case of pregnancy-induced hypertension with serous retinal detachment
    American Journal of Ophthalmology Case Reports, 100911, doi:10.1016/j.ajoc.2020.100911, 2020. [Link]
  15. Takatoshi Maeno, Kenichiro Aso, Ryuya Hashimoto and Hidetaka Masahara
    Improving blood flow in occluded veins to reduce anti-vascular endothelial growth factor injections for branch retinal vein occlusion
    American Journal of Ophthalmology Case Reports, 30, 101847, doi:10.1016/j.ajoc.2023.101847, 2023. [Link]
  16. Takatoshi Maeno, Ryuya Hashimoto, Sonoko Isa, Keisuke Yata and Hidetaka Masahara
    Time course of choroidal blood flow during anti-VEGF treatment for pachychoroid disease
    Investigative Ophthalmology and Visual Science, 64(8), 1995, 2023 ARVO Annual Meeting abstract, 2023.
  17. Otsuka Yuki, Maeno Takatoshi, Hashimoto Ryuya
    Choroidal and Retinal Blood Flow Changes Following Vitrectomy in Two Cases of Postoperative Endophthalmitis
    Cureus, Jan 2025. doi:10.7759/cureus.77006 [Link]
  18. Hashimoto Ryuya, Tanaka Kazufumi, Fujioka Naoki, Nunose Moe, Imai Sara, Moriyama Serika, Hitaka Mai, Yamazaki Keisuke, Yagi Fumihiko, Ohashi Yasushi
    Choroidal Microcirculatory Responses to Hemodialysis in Patients With Diabetic Nephropathy and Retinopathy
    Microcirculation, 33(2), Feb 2026. doi:10.1111/micc.70055 [Link]
  19. Hashimoto Ryuya, Oka Ryo, Fujioka Naoki, Tanaka Kazufumi, Nunose Moe, Imai Sara, Takenaka Ryota, Noro Takahide, Somoto Takatoshi, Utsumi Takanobu, Kamiya Naoto, Yagi Fumihiko, Suzuki Hiroyoshi
    Impact of Androgen Deprivation Therapy on Choroidal Microcirculation Assessed Using Laser Speckle Flowgraphy
    Microcirculation, 33(1), Jan 2026. doi:10.1111/micc.70048 [Link]
  20. Hashimoto Ryuya, Kardon Randy H.
    Laser speckle flowgraph reveals dynamic characteristics and clinical relevance of choroidal watershed and peripapillary hypoperfusion zones
    Sci Rep, Apr 2026. doi:10.1038/s41598-026-47062-z [Link]
  21. Hashimoto Ryuya, Fujioka Naoki, Tanaka Kazufumi, Moriyama Serika, Maeno Takatoshi
    Intraoperative Ocular Blood Flow Dynamics in Response to Intraocular Pressure Fluctuations During Vitrectomy for Proliferative Diabetic Retinopathy
    JCM, 15(5), 2080, Mar 2026. doi:10.3390/jcm15052080 [Link]
  22. Hashimoto Ryuya, Kawamura Juri, Fujioka Naoki, Tanaka Kazufumi, Nunose Moe, Imai Sara, Moriyama Serika, Yamazaki Ryo, Hirota Asato, Yagi Fumihiko
    Choroidal Thickening and Reduced Macular Blood Flow in Children with Hyperopic Anisometropic Amblyopia
    JCM, 15(5), 2085, Mar 2026. doi:10.3390/jcm15052085 [Link]

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Department of Ophthalmology, Toho University Omori Medical Center

  1. Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Yuuji Katayama, Tetsushi Arimura, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
    Reproducibility of Neonate Ocular Circulation Measurements using Laser Speckle Flowgraphy
    BioMed Research International, 2015. doi:10.1155/2015/693056 [Link]
  2. Tomoaki Shiba, Tetsuya Sugiyama, Yuichi Hori, Tadashi Matsumoto, Takatoshi Maeno and Mao Takahashi
    Relationship between plasma levels of vasoactive mediators and optic nerve head circulation shown by laser speckle flowgraphy
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-015-3145-5, 2015. [Link]
  3. Tomoaki Shiba , Mao Takahashi, Ryuya Hashimoto, Tadashi Matsumoto and Yuichi Hori
    Pulse waveform analysis in the optic nerve head circulation reflects systemic vascular resistance obtained via a Swan–Ganz catheter.
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3289-y, 2016. [Link]
  4. Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Yuuji Katayama, Tetsushi Arimura, Kotaro Hine, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
    Ocular blood flow values measured by laser speckle flowgraphy correlate with the postmenstrual age of normal neonates
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3362-6, 2016. [Link]
  5. Chieko Shiba, Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
    Relationship between glycosylated hemoglobin A1c and ocular circulation by laser speckle flowgraphy in patients with/without diabetes mellitus
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3437-4, 2016. [Link]
  6. Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Kohji Shirai and Yuichi Hori
    Arterial stiffness shown by the cardio-ankle vascular index is an important contributor to optic nerve head microcirculation
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3521-9, 2016. [Link]
  7. Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori and Kohji Shirai
    Arterial Stiffness, Monitored with Cardio Ankle Vascular Index is Adjusting The Ocular Microcirculation Obtained from Laser Speckle Flowgraphy.
    Journal of Hypertension, doi: 10.1097/01.hjh.0000501307.42081.00, 2016. [Link]
  8. Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Kotaro Hine and Yuichi Hori
    A Change in Ocular Circulation after Photocoagulation for Retinopathy of Prematurity in a Neonate
    Case Reports in Ophthalmology, 8(1), 91-98, doi: 10.1159/000456708, 2017. [Link]
  9. Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
    Differences in optic nerve head microcirculation between evening and morning in patients with coronary artery disease
    Microcirculation, doi: 10.1111/micc.12386, 2017. [Link]
  10. Tadashi Matsumoto, Yuta Saito, Takashi Itokawa, Tomoaki Shiba, Mari S. Oba, Haruo Takahashi and Yuichi Hori
    Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-017-3756-0, 2017. [Link]
  11. Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
    Relationship between Metabolic Syndrome and Ocular Microcirculation Shown by Laser Speckle Flowgraphy in a Hospital Setting Devoted to Sleep Apnea Syndrome Diagnostics
    Journal of Diabetes Research, doi: 10.1155/2017/3141678, 2017. [Link]
  12. Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Masahiko Tomita, Kotaro Hine, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
    Decreased ocular blood flow after photocoagulation therapy in neonatal retinopathy of prematurity
    Japanese journal of ophthalmology, doi: 10.1007/s10384-017-0536-7, 2017. [Link]
  13. Hironori Osamura, Tomoaki Shiba, Takashi Itokawa, Tadashi Matsumoto and Yuichi Hori
    Relationships among Ocular Blood Flow Shown by Laser Speckle Flowgraphy, Retinal Arteriosclerotic Change, and Chorioretinal Circulation Time Obtained by Fluorescein Angiography
    Journal of Ophthalmology, doi: 10.1155/2017/2969064, 2017. [Link]
  14. Tomoaki Shiba, Mao Takahashi, Chieko Shiba, Tadashi Matsumoto and Yuichi Hori
    The relationships between the pulsatile flow form of ocular microcirculation by laser speckle flowgraphy and the left ventricular end-diastolic pressure and mass
    The International Journal of Cardiovascular Imaging, doi: 10.1007/s10554-018-1388-z, 2018. [Link]
  15. Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Masahiko Tomita, Kotaro Hine, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
    Intravitreal bevacizumab treatment reduces ocular blood flow in retinopathy of prematurity: a four-case report
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-018-4063-0, 2018. [Link]
  16. Tetsushi Arimura, Tomoaki Shiba, Mao Takahashi, Shun Kumashiro, Hironori Osamura. Tadashi Matsumoto, Ken Sakai and Yuichi Hori
    Assessment of ocular microcirculation in patients with end-stage kidney disease
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-018-4137-z, 2018. [Link]
  17. Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
    Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction
    Journal of vascular research, 55(6), 329-337, doi:10.1159/000494066, 2018. [Link]
  18. Tatsuhiko Kobayashi, Tomoaki Shiba, Ayako Kinoshita, Tadashi Matsumoto and Yuichi Hori
    The influences of gender and aging on optic nerve head microcirculation in healthy adults
    Scientific Reports, 9(1), 15636, doi:10.1038/s41598-019-52145-1, 2019. [Link]
  19. Tatsuhiko Kobayashi, Tomoaki Shiba, Yuji Nishiwaki, Ayako Kinoshita, Tadashi Matsumoto and Yuichi Hori
    Influence of age and gender on the pulse waveform in optic nerve head circulation in healthy men and women
    Scientific Reports, 9(1), 17895, doi:10.1038/s41598-019-54470-x, 2019. [Link]
  20. Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
    Gender differences in the influence of obstructive sleep apnea on optic nerve head circulation
    Scientific Reports, 9(1), 18849, doi:10.1038/s41598-019-55470-7, 2019. [Link]
  21. Takashi Itokawa, Takashi Suzuki, Yukinobu Okajima, Tatsuhiko Kobayashi, Hiroko Iwashita, Satoshi Gotoda, Koji Kakisu, Yuto Tei and Yuichi Hori
    Correlation between Blood Flow and Temperature of the Ocular Anterior Segment in Normal Subjects
    Diagnostics, 10(9), 695, doi:10.3390/diagnostics10090695, 2020. [Link]
  22. Shun Kumashiro, Seiji Takagi, Takashi Itokawa, Akiko Tajima, Tatsuhiko Kobayashi and Yuichi Hori
    Decrease in choroidal blood flow after half and one-third dose verteporfin photodynamic therapy for chronic central serous chorioretinopathy
    BMC Ophthalmology, 21(1), 1-8, doi:10.1186/s12886-021-01980-w, 2021. [Link]
  23. Kento Watanabe, Tomoaki Shiba, Tetsuya Komatsu, Kiyoshi Sakuma, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara and Yuichi Hori
    The influence of hemorrhagic shock on ocular microcirculation by obtained by laser speckle flowgraphy in a white rabbit model
    Microcirculation, e12716, doi:10.1111/micc.12716, 2021. [Link]
  24. Takashi Itokawa, Sayaka Sumazaki, Yukinobu Okajima, Koji Kakisu, Takashi Suzuki and Yuichi Hori
    Changes in ocular anterior segment blood flow and temperature after thermal pulsation treatment in patients with meibomian gland dysfunction
    Investigative Ophthalmology and Visual Science, 62(8), 1239, 2021 ARVO Annual Meeting abstract, 2021.
  25. Tetsuya Komatsu, Tomoaki Shiba, Kento Watanabe, Kiyoshi Sakuma, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara and Yuichi Hori
    Real-Time Evaluation of Regional Arterial Stiffening, Resistance, and Ocular Circulation During Systemic Administration of Adrenaline in White Rabbits
    Translational Vision Science and Technology, 10(9), 11-11, doi:10.1167/tvst.10.9.11, 2021. [Link]
  26. Tatsuhiko Kobayashi, Tomoaki Shiba, Kenji Okamoto, Tomohiko Usui and Yuichi Hori
    Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-022-05631-8, 2022. [Link]
  27. Takashi Itokawa, Yukinobu Okajima, Hiroko Iwashita, Koji Kakisu and Yuichi Hori
    Effect of wind stimulation on ocular surface temperatures and blood flow in soft contact lens wearers
    Investigative Ophthalmology and Visual Science, 63(7), 520-A0218, 2022 ARVO Annual Meeting abstract, 2022.
  28. Takashi Itokawa, Yukinobu Okajima, Hiroko Iwashita, Kakisu Koji, Takashi Suzuki and Yuichi Hori
    Association between mask-associated dry eye (MADE) and corneal sensations
    Scientific Reports, 13(1), 1625, doi:10.1038/s41598-022-23994-0, 2023. [Link]
  29. Takashi Itokawa, Tadashi Matsumoto, Saiko Matsumura, Momoko Kawakami and Yuichi Hori
    Ocular blood flow evaluation by laser speckle flowgraphy in pediatric patients with anisometropia
    Frontiers in Public Health, 11, 1093686, doi:10.3389/fpubh.2023.1093686, 2023. [Link]
  30. Kento Watanabe, Tomoaki Shiba, Akira Takahara, Hiroshi Homma, Tetsuya Komatsu, Yusuke Tanino, Yoshinobu Nagasawa, Megumi Aimoto and Yuichi Hori
    Evaluating the relationship between ocular blood flow and systemic organ blood flow in hemorrhagic shock using a rabbit model
    Scientific Reports, 14(1), 3749, doi:10.1038/s41598-024-54467-1, 2024. [Link]
  31. Takashi Itokawa, Yukinobu Okajima, Hiroko Iwashita, Kakisu Koji, Shigeki Tashiro, Takashi Suzuki and Yuichi Hori
    Association between dryness sensation and ocular surface temperature and conjunctival blood flow in soft contact lens wearers
    Contact Lens and Anterior Eye, 102166, doi:10.1016/j.clae.2024.102166, 2024. [Link]
  32. Naoko Wada, Seiji Takagi, Akiko Yoshikawa, Takashi Itokawa, Takahiro Maruyama and Yuichi Hori
    Multimodal Imaging of Optic Nerve Head in Retinitis Pigmentosa
    Seminars in Ophthalmology, 39(6), 480-487, doi:10.1080/08820538.2024.2363849, 2024. [Link]
  33. Magi Shigeyuki, Maruyama Takahiro, Takagi Seiji, Naito Atsuhiko T., Hori Yuichi
    Machine learning assessment of retinal blood flow links metabolic dysfunction and accelerated microvascular aging
    Sci Rep, 16(1), Jan 2026. doi:10.1038/s41598-025-32776-3 [Link]

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Department of Ophthalmology, Toho University Ohashi Medical Center

  1. Ayako Anraku, Kyoko Ishida, Nobuko Enomoto, Seiji Takagi, Hiroyuki Ito, Asuka Takeyama, Fumihiko Yagi and Goji Tomita
    Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect
    Journal of Ophthalmology, doi: 10.1155/2017/3608396, 2017. [Link]
  2. Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida and Goji Tomita
    Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma
    Journal of Ophthalmology, doi: 10.1155/2018/1751857, 2018. [Link]
  3. Haruka Moroi, Ayako Anraku, Kyoko Ishida and Goji Tomita
    Factors Related to a Right-Left Difference in Visual Field Defect in the Eyes with Untreated Normal Tension Glaucoma
    Journal of Ophthalmology, doi: 10.1155/2018/4595214, 2018. [Link]
  4. Satoko Masai, Kyoko Ishida, Ayako Anraku, Tetsuro Takumi and Goji Tomita
    Pulse Waveform Analysis of the Ocular Blood Flow Using LaserSpeckle Flowgraphy before and after Glaucoma Treatment
    Journal of Ophthalmology, doi: 10.1155/2019/1980493, 2019. [Link]
  5. Ayako Anraku, Nobuko Enomoto, Goji Tomita, Aiko Iwase, Takashi Sato, Nobuyuki Shoji, Tomoaki Shiba, Toru Nakazawa, Kazuhisa Sugiyama, Koji Nitta and Makoto Araie
    Ocular and Systemic Factors Affecting Laser Speckle Flowgraphy Measurements in the Optic Nerve Head
    Translational Vision Science & Technology, 10(1), 13, doi:10.1167/tvst.10.1.13, 2021. [Link]
  6. Nobuko Enomoto, Ayako Anraku, Goji Tomita, Aiko Iwase, Takashi Sato, Nobuyuki Shoji, Tomoaki Shiba, Toru Nakazawa, Kazuhisa Sugiyama, Koji Nitta and Makoto Araie
    Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
    Scientific Reports, 11(1), 1-12, doi:10.1038/s41598-021-86280-5, 2021. [Link]

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Department of Neurosurgery, Toho University Ohashi Medical Center

  1. Masashi Ishii, Morito Hayashi, Fumihiko Yagi, Kenichiro Sato, Goji Tomita and Satoshi Iwabuchi
    Relationship between the Direction of Ophthalmic Artery Blood Flow and Ocular Microcirculation before and after Carotid Artery Stenting.
    Journal of Ophthalmology, doi: 10.1155/2016/2530914, 2016. [Link]

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Department of Ophthalmology, University of Tokyo

  1. Yasuhiro Tamaki, Eizo Kawamoto, Shuichiro Eguchi, Makoto Araie and Hitoshi Fujii
    An Application of laser speckle phenomenon for non-invasive 2-dimensional evaluation of microcirculation in ocular fundus
    Jpn. J. Ophthalmol, 37, no.2, 178-186, 1993.
  2. Y. Tamaki, M. Araie, E. Kawamoto, S. Eguchi and H. Fujii
    Noncontact, Two-Dimensional Measurement of Retinal Microcirculation Using Laser Speckle Phenomenon Invest.
    Ophthalmol. Vis. Sci., 35, no.11, 3825-3834, 1994.
  3. Y. Tamaki, M. Araie, E. Kawamoto, S. Eguchi and H. Fujii
    Noncontact, Two-Dimensional Measurement of Tissue Circulation in Choroid and Optic Nerve Head Using Laser Speckle Phenomenon
    Exp. Eye Res., 60, 373-384, 1995.
  4. Y.Tamaki and M. Araie
    Time Change of Nicardipine Effect on Tissue Circulation in Retina in Living Rabbit eyes
    Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995 doi:10.3109/02713689609000765 [Link]
  5. Y. Tamaki, M. Araie, K. Tomita, M. Nagahara, A. Tomidokoro and H. Fujii
    Real-Time Measurement of Human Optic Nerve Head and Choroid Circulation, Using the Laser Speckle Phenomenon
    Jpn. J Ophthalmol., 41, 49-54, 1997. doi:10.1016/s0021-5155(96)00008-1 [Link]
  6. Miyuki Nagahara, Yasuhiro Tamaki, Atsuo Tomidokoro and Makoto Araie
    In Vivo Measurement of Blood Velocity in Human Major Retinal Vessels Using the Laser Speckle Method
    Invest. Ophthalmol. Vis. Sci. August 11, 2010 doi:10.1167/iovs.09-4422 [Link]
  7. Chihiro Mayama
    Calcium channels and their blockers in intraocular pressure and glaucoma
    European Journal of Pharmacology, Available online 1 December 2013. doi:10.1016/j.ejphar.2013.10.073 [Link]

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Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University

  1. Hidetaka Noma, Kanako Yasuda, Terumi Minezaki, Sho Watarai, and Masahiko Shimura
    Changes of retinal flow volume after intravitreal injection of bevacizumab in branch retinal vein occlusion with macular edema: a case series
    BMC ophthalmology, 16(1), 61, doi:10.1186/s12886-016-0239-8, 2016. [Link]
  2. Hidetaka Noma, Kanako Yasuda, Tatsuya Mimura, Akemi Ofusa, and Masahiko Shimura
    Relationship between retinal blood flow and cytokines in central retinal vein occlusion
    BMC Ophthalmology, 20(1), 215, doi:10.1186/s12886-020-01486-x, 2020. [Link]
  3. Toru Mizui, Hidetaka Noma, Kanako Yasuda, Tomoe Kanemaki, Hiroshi Goto and Masahiko Shimura
    Intravitreal ranibizumab reduced ocular blood flow and aqueous cytokine levels and improved retinal morphology in patients with diabetic macular edema
    Scientific Reports, 10(1), 1-8, doi:10.1038/s41598-020-78792-3, 2020. [Link]
  4. Hidetaka Noma, Kanako Yasuda, Tatsuya Mimura, Noboru Suganuma and Masahiko Shimura
    Retinal Microcirculation and Cytokines as Predictors for Recurrence of Macular Edema after Intravitreal Ranibizumab Injection in Branch Retinal Vein Occlusion
    Journal of Clinical Medicine, 10(1), 58, doi:10.3390/jcm10010058, 2020. [Link]
  5. Yurika Takano, Hidetaka Noma, Kanako Yasuda, Tomoe Yamaguchi, Hiroshi Goto and Masahiko Shimura
    Retinal Blood Flow as a Predictor of Recurrence of Macular Edema after Intravitreal Ranibizumab Injection in Central Retinal Vein Occlusion
    Ophthalmic Research, doi:10.1159/000519150, 2021. [Link]
  6. Kanako Yasuda, Hidetaka Noma, Tatsuya Mimura, Ryota Nonaka, Shotaro Sasaki, Noboru Suganuma and Masahiko Shimura
    Effects of Intravitreal Ranibizumab Injection on Peripheral Retinal Microcirculation and Cytokines in Branch Retinal Vein Occlusion with Macular Edema
    Medicina, 59(6), 1053, doi:10.3390/medicina59061053, 2023. [Link]
  7. Kanako Yasuda, Hidetaka Noma, Eri Oyama, Kosei Yanagida, Masaki Asakage and Masahiko Shimura
    Effects of Intravitreal Ranibizumab Injection to Treat Macular Edema due to Central Retinal Vein Occlusion on Choroidal Findings and Functional-Morphological Parameters
    Ophthalmic Research, doi:10.1159/000531498, 2023. [Link]

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Department of Ophthalmology, Tokyo Medical and Dental University

  1. Ryoko Soma, Muka Moriyama and Kyoko Ohno-Matsui
    Hemodynamics of focal choroidal excavations
    International Ophthalmology, 1-8, 2015. doi:10.1007/s10792-015-0042-1 [Link]

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Division of Ophthalmology, Nihon University

  1. Taiji Nagaoka, HIrotsugu Hanazaki, Hiroyuki Nakashizuka, Hajime Onoe, Hiroshi Aso, Junya Hanaguri, Masahisa Watanabe, Harumasa Yokota and Satoru Yamagami
    Evaluation of ocular blood flow in response to induced systemic hyperoxia using a Laser Speckle Flowgraphy in anesthetized pigs
    Investigative Ophthalmology & Visual Science, 61(7), 1742, 2020.
  2. Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Lih Kuo, Satoru Yamagami and Taiji Nagaoka
    Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy
    Scientific Reports, 10(1), 1-9, doi:10.1038/s41598-020-75296-y, 2020. [Link]
  3. Hirotsugu Hanazaki, Harumasa Yokota, Hiroshi Aso, Satoru Yamagami and Taiji Nagaoka
    Evaluation of ocular blood flow over time in a treated retinal arterial macroaneurysm using laser speckle flowgraphy
    American journal of ophthalmology case reports, 21, 101022, doi:10.1016/j.ajoc.2021.101022, 2021. [Link]
  4. Harumasa Yokota, Taiji Nagaoka, Hidetaka Noma, Akemi Ofusa, Tomoe Kanemaki, Hiroshi Aso, Hirotsugu Hanazaki, Satoru Yamagami and Masahiko Shimura
    Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
    Scientific Reports, 11(1), 1-8, doi:10.1038/s41598-021-94993-w, 2021. [Link]
  5. Hanaguri J, Yokota H, Watanebe M, Yamagami S, Kushiyama A, Kuo L, Nagaoka T.
    Retinal Blood Flow Dysregulation Precedes Neural Retinal Dysfunction in Type 2 Diabetic Mice.
    Scientific Reports, 11(1), 1-11, doi:10.1038/s41598-021-97651-3, 2021. [Link]
  6. Yasunari Ebuchi, daisuke fukamachi, Keisuke Kojima, Taiji Nagaoka, Nobuhiro Murata, Akihito Ohgaku, Yutaka Koyama, Hidesato Fujito, Riku Arai, Masaki Monden, Takehiro Tamaki, Daisuke Kitano, Yasuo Okumura, Satoru Yamagami
    Comprehensive Assessment of Systemic Atherosclerosis in Relation to the Ocular Resistive Index in Acute Coronary Syndrome Patients.
    Circulation, 144(Suppl_1), A8881-A8881, 2021. doi:10.1161/circ.144.suppl_1.8881 [Link]
  7. Harumasa Yokota, Hiroki Hayashi, Junya Hanaguri, Satoru Yamagami, Akifumi Kushiyama, Hironori Nakagami and Taiji Nagaoka
    Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes
    PLOS ONE, 17(1), e0262568, doi:10.1371/journal.pone.0262568, 2022. [Link]
  8. Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Masahisa Watanabe, Satoru Yamagami and Taiji Nagaoka
    The Effect of Sodium-Dependent Glucose Cotransporter 2 Inhibitor Tofogliflozin on Neurovascular Coupling in the Retina in Type 2 Diabetic Mice
    International Journal of Molecular Sciences, 23(3), 1362, doi:10.3390/ijms23031362, 2022. [Link]
  9. Hanaguri Junya, Yokota Harumasa, Kushiyama Akifumi, Kushiyama Sakura, Watanabe Masahisa, Yamagami Satoru, Nagaoka Taiji
    Beneficial Effect of Long-Term Administration of Supplement With Trapa Bispinosa Roxb. and Lutein on Retinal Neurovascular Coupling in Type 2 Diabetic Mice
    Front. Physiol., 13, Feb 2022. doi:10.3389/fphys.2022.788034 [Link]
  10. Junya Hanaguri, Noriaki Nagai, Harumasa Yokota, Akifumi Kushiyama, Masahisa Watanabe, Satoru Yamagami and Taiji Nagaoka
    Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice
    Pharmaceutics, 14(2), 384, doi:10.3390/pharmaceutics14020384, 2022. [Link]
  11. Taiji Nagaoka, Yasunari Ebuchi, Akifumi Kushiyama, Daisuke Fukamachi, Harumasa Yokota, Satoru Yamagami and Yasuo Okumura
    Relation between choroidal blood flow parameters and systemic atherosclerosis in patients with acute coronary syndrome
    Investigative Ophthalmology and Visual Science, 64(8), 458, 2023 ARVO Annual Meeting abstract, 2023.
  12. Ruri Sugiyama, Takako Ohnishi, Satoru Yamagami and Taiji Nagaoka
    A case of acute syphilitic posterior placoid chorioretinitis showing improved choroidal blood flow after treatment
    American Journal of Ophthalmology Case Reports, 32, 101880, doi:10.1016/j.ajoc.2023.101880, 2023. [Link]
  13. Taiji Nagaoka, Harumasa Yokota, Masahisa Watanabe, Hiroshi Aso, Koyo Takase, Junya Hanaguri, Akira Ohno, Akifumi Kushiyama, Seiyo Harino and Satoru Yamagami
    Impairment of flicker-induced increase in retinal blood flow in diabetic pigs
    Japanese Journal of Ophthalmology, doi:10.1007/s10384-024-01073-3, 2024. [Link]
  14. Yoshinari Saima, Harumasa Yokota, Akifumi Kushiyama, Junya Hanaguri, Akira Ohno, Koyo Takase, Ruri Sugiyama, Kimimasa Muranaka, Satoru Yamagami and Taiji Nagaoka
    Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema
    Scientific Reports, 14, doi:10.1038/s41598-024-63435-8, 2024. [Link]
  15. Ruri Sugiyama, Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Takako Kikuchi, Tsutomu Igarashi, Masumi Iketani, Ikuroh Ohsawa, Seiyo Harino, Hiroyuki Nakashizuka, Satoru Yamagami and Taiji Nagaoka
    Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice
    Translational Vision Science and Technology, 13(10), 36, doi:10.1167/tvst.13.10.36, 2024. [Link]

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Division of Cardiology, Nihon University

  1. Yasunari Ebuchi, Taiji Nagaoka, Daisuke Fukamachi, Keisuke Kojima, Naotaka Akutsu, Nobuhiro Murata, Yuki Saito, Daisuke Kitano, Harumasa Yokota, Satoru Yamagami and Yasuo Okumura
    Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients
    Scientific Reports, 12(1), 1-11, doi:10.1038/s41598-021-04196-6, 2022. [Link]

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Department of Ophthalmology, Kyorin University

  1. Toshiki Watanabe, Yukihiko Mashima, Kazuteru Kigasawa, Asako Mashima, Masahiko Shimura and Akito Hirakata
    Increased Microcirculation on Optic Nerve Head by Laser Speckle Flowgraphy at Early Stage of Leber Hereditary Optic Neuropathy
    Neuro-Ophthalmology, 43(6), 411-416, doi:10.1080/01658107.2018.1526956, 2018. [Link]

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Tokyo Institute of Technology

  1. Tsukasa Ikemura, Akane Miyaji, Hideaki Kashima, Yuji Yamaguchi, Naoyuki Hayashi
    Ocular blood flow decreases during passive heat stress in resting humans
    Journal of Physiological Anthropology 2013, 32:23 doi:10.1186/1880-6805-32-23 [Link]
  2. Tsukasa Ikemura, Naoyuki Hayashi
    Effects of Heat Stress on Ocular Blood Flow during Exhaustive Exercise
    Journal of Sports Science and Medicine (2014) 13, 172-179
  3. Kashima H., Hamada Y., Hayashi N.
    Palatability of Tastes Is Associated With Facial Circulatory Responses
    Chemical Senses, 39(3), 243-248, Mar 2014. doi:10.1093/chemse/bjt074 [Link]
  4. A. Miyaji, T. Ikemura, Y. Hamada and N. Hayashi
    Regional differences in the vascular response to CO 2 among cerebral, ocular, and mesenteric vessels.
    Artery Research, Available online 6 September 2015. doi:10.1016/j.artres.2015.08.001 [Link]
  5. A. Miyaji, T. Ikemura and N. Hayashi
    Effect of Aging on the Blowout Time in Various Ocular Vessels
    Aging Sci, 4(148), 2, 2016 doi:10.4172/2329-8847.1000148 [Link]
  6. Naoyuki Hayashi, Lanfei Du
    Acute and Chronic Periocular Massage for Ocular Blood Flow and Vision: a Randomized Controlled Trial
    International Journal of Therapeutic Massage & Bodywork, 14(2), 5-13, 2021. doi:10.3822/ijtmb.v14i2.583 [Link]
  7. Chihyun Liu, Tatsuhiko Kobayashi, Tomoaki Shiba and Naoyuki Hayashi
    Effects of aging and exercise habits on blood flow profile of the ocular circulation
    PLOS ONE, 17(4), e0266684, doi:10.1371/journal.pone.0266684, 2022. [Link]

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Faculty of Sport Sciences, Waseda University

  1. Tsukasa Ikemura, Hideaki Kashima, Yuji Yamaguchi, Akane Miyaji and Naoyuki Hayashi
    Inner ocular blood flow responses to an acute decrease in blood pressure in resting humans
    Physiological measurement, 36(2), 219. doi:10.1088/0967-3334/36/2/219 [Link]

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Faculty of Commerce, Yokohama College of Commerce

  1. Tsukasa Ikemura, Naoyuki Hayashi
    Inner ocular blood flow response to exercise in healthy humans
    The Journal of Physical Fitness and Sports Medicine, 6(4), 223-226, doi:10.7600/jpfsm.6.223, 2017. [Link]
  2. Tsukasa Ikemura, Katsuhiko Suzuki, Nobuhiro Nakamura, Koichi Yada and Naoyuki Hayashi
    Fluid intake restores retinal blood flow early after exhaustive exercise in healthy subjects
    European Journal of Applied Physiology, doi:10.1007/s00421-018-3839-6, 2018. [Link]

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College of Liberal Arts and Science, Kitasato University

  1. Tsukasa Ikemura, Nobuhiro Nakamura, and Naoyuki Hayashi
    Impact of acute dynamic exercise on vascular stiffness in the retinal arteriole in healthy subjects
    Journal of Applied Physiology, 132(2). 459-468, doi:10.1152/japplphysiol.00507.2021, 2021. [Link]

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Ophthalmology and Visual Science, Kanazawa University

  1. Yasushi Wada, Tomomi Higashide, Atsushi Nagata and Kazuhisa Sugiyama
    Longitudinal Changes in Optic Nerve Head Blood Flow in Normal Rats Evaluated by Laser Speckle Flowgraphy.
    IOVS, 57(13), 5568-5575, 2016. doi:10.1167/iovs.16-19945 [Link]
  2. Yutaro Yamada, Tomomi Higashide, Sachiko Udagawa, Satoshi Takeshima, Kimikazu Sakaguchi, Koji Nitta and Kazuhisa Sugiyama
    The Relationship Between Interocular Asymmetry of Visual Field Defects and Optic Nerve Head Blood Flow in Patients with Glaucoma
    Journal of Glaucoma、doi:10.1097/IJG.0000000000001181, 2018. [Link]
  3. Yasushi Wada, Tomomi Higashide, Atsushi Nagata and Kazuhisa Sugiyama
    Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-018-4191-6, 2018. [Link]
  4. Satoshi Takeshima, Tomomi Higashide, Masayo Kimura, Sachiko Udagawa, Yutaro Yamada, Daisuke Takemoto, Shinji Ohkubo and Kazuhisa Sugiyama
    Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma
    Investigative Ophthalmology & Visual Science, 60(2), 677-684, doi:10.1167/iovs.18-25694, 2019. [Link]
  5. Yuki Takamatsu, Tomomi Higashide, Satoshi Takeshima, Makoto Sasaki, Yoshimi Manbo, Sachiko Udagawa, Shinji Ohkubo, Shozo Sonoda, Taiji Sakamoto and Kazuhisa Sugiyama
    Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy
    Translational Vision Science and Technology, 10(14), 30, doi:10.1167/tvst.10.14.30, 2021. [Link]
  6. Makoto Sasaki, Tomomi Higashide, Satoshi Takeshima, Yuki Takamatsu, Yoshimi Manbo, Sachiko Udagawa and Kazuhisa Sugiyama
    Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma
    Scientific Reports, 12(1), 9802, doi:10.1038/s41598-022-13989-2, 2022. [Link]
  7. Yasushi Wada, Tomomi Higashide, Kimikazu Sakaguchi, Atsushi Nagata, Kazuyuki Hirooka and Kazuhisa Sugiyama
    Compromised blood flow in the optic nerve head after systemic administration of 2 aldosterone in rats: A possible rat model of retinal ganglion cell loss
    Current Eye Research, doi:10.1080/02713683.2022.2029907, 2022. [Link]

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Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University

  1. Nakano Y., Suzuki Y., Takagi T., Kitashoji A., Ono Y., Tsuruma K., Yoshimura S., Shimazawa M., Iwama T., Hara H.
    Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia–reperfusion injury
    Neuroscience, 277, 123-131, Sep 2014. doi:10.1016/j.neuroscience.2014.06.065 [Link]
  2. Shinichiro Fuma, Anri Nishinaka, Yuki Inoue, Kazuhiro Tsuruma, Masamitsu Shimazawa, Mineo Kondo and Hideaki Hara
    A pharmacological approach in newly established retinal vein occlusion model
    Scientific Reports, 7, doi:10.1038/srep43509, 2017. [Link]
  3. Mayu Moriguchi, Shinsuke Nakamura, Yuki Inoue, Anri Nishinaka, Maho Nakamura, Masamitsu Shimazawa and Hideaki Hara
    Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation
    Investigative Ophthalmology & Visual Science, 59(8), 3476-3487, 2018. doi:10.1167/iovs.17-23532 [Link]
  4. Anri Nishinaka, Yuki Inoue, Shinichiro Fuma, Yoshifumi Hida, Shinsuke Nakamura, Masamitsu Shimazawa and Hideaki Hara
    Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion
    Investigative Ophthalmology & Visual Science, 59(11), 4701-4713, 2018. doi:10.1167/iovs.18-23994 [Link]
  5. Anri Nishinaka, Koki Nitta, Takashi Seki, Hideaki Hara and Masamitsu Shimazawa
    The Changes in Blood Flow Seen in the Eye after Foot Acupuncture Treatment in Mice
    Evidence-Based Complementary and Alternative Medicine, 2020, 6405471, doi: 10.1155/2020/6405471, 2020. [Link]
  6. Shinsuke Nakamura, Anri Nishinaka, Yae Hidaka, Masamitsu Shimazawa, Leo Thomas, Remko A. Bakker and Hideaki Hara
    Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model
    Investigative Ophthalmology and Visual Science, 63(8), 14, doi: 10.1167/iovs.63.8.14, 2022. [Link]
  7. Anri Nishinaka, Miruto Tanaka, Kentaro Ohara, Eiji Sugaru, Yuji Shishido, Akemi Sugiura, Yukiko Moriguchi, Amane Toui, Shinsuke Nakamura, Kaoru Shimada, Shuzo Watanabe, Hideaki Hara and Masamitsu Shimazawa
    TRPV4 channels promote vascular permeability in retinal vascular disease
    Experimental Eye Research, 228, 109405, doi: 10.1016/j.exer.2023.109405, 2023. [Link]

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Department of Ophthalmology, Nagoya University

  1. Furuta Toshiaki, Sone Michihiko, Fujimoto Yasushi, Yagi Shunjiro, Sugiura Makoto, Kamei Yuzuru, Fujii Hitoshi, Nakashima Tsutomu
    Free Flap Blood Flow Evaluated Using Two-Dimensional Laser Speckle Flowgraphy
    International Journal of Otolaryngology, 2011, 1-6, 2011. doi:10.1155/2011/297251 [Link]
  2. Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Kenta Murotani, Shigeyuki Matsui, and Hiroko Terasaki
    Diurnal Variations in Blood Flow at Optic Nerve Head and Choroid in Healthy Eyes: Diurnal Variations in Blood Flow.
    Medicine, 94(6): e819, 2015. doi:10.1097/MD.0000000000000519 [Link]
  3. Kosei Yanagida, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Hiroki Kaneko, Kenta Murotani, Shigeyuki Matsui and Hiroko Terasaki
    Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy.
    IOVS, 56(8), 4880-4890, 2015. doi:10.1167/iovs.15-16567 [Link]
  4. Takeshi Iwase, Eimei Ra, Kentaro Yamamoto, Hiroki Kaneko, Yasuki Ito and Hiroko Terasaki
    Differences of Retinal Blood Flow Between Arteries and Veins Determined by Laser Speckle Flowgraphy in Healthy Subjects
    Medicine, 94(33): e1256, 2015. doi:10.1097/MD.0000000000001256 [Link]
  5. Takeshi Iwase, Kentaro Yamamoto, Misato Kobayashi, Eimei Ra, Kenta Murotani and Hiroko Terasaki
    What ocular and systemic variables affect choroidal circulation in healthy eyes
    Medicine, 95(43): e5102, 2016. doi:10.1097/MD.0000000000005102 [Link]
  6. Takeshi Iwase, Misato Kobayashi, Kentaro Yamamoto, Kosei Yanagida, Eimei Ra and Hiroko Terasaki
    Changes in Blood Flow on Optic Nerve Head After Vitrectomy for Rhegmatogenous Retinal Detachment
    IOVS, 57(14), 6223-6233, 2016. doi:10.1167/iovs.16-20577 [Link]
  7. Marie Fukami, Takeshi Iwase, Kentaro Yamamoto, Hiroki Kaneko, Shunsuke Yasuda and Hiroko Terasaki
    Changes in Retinal Microcirculation After Intravitreal Ranibizumab Injection in Eyes With Macular Edema Secondary to Branch Retinal Vein Occlusion
    IOVS, 58(2), 1246-1255, 2017. doi:10.1167/iovs.16-21115 [Link]
  8. Takeshi Iwase, Misato Kobayashi, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
    Effects of photocoagulation on ocular blood flow in patients with severe non-proliferative diabetic retinopathy
    PLOS ONE, 12(3), e0174427, doi:10.1371/journal.pone.0174427, 2017. [Link]
  9. Marie Fukami, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Kenta Murotani and Hiroko Terasaki
    Diurnal variation of pulse waveform parameters determined by laser speckle flowgraphy on the optic nerve head in healthy subjects.
    Medicine, 96(44): e8312, 2017. doi:10.1097/MD.0000000000008312 [Link]
  10. Takeshi Iwase, Misato Kobayashi, Kentaro Yamamoto, Kosei Yanagida, Eimei Ra and Hiroko Terasaki
    Change in choroidal blood flow and choroidal morphology due to segmental scleral buckling in eyes with rhegmatogenous retinal detachment
    Scientific Reports, 7(1), 5997, doi:10.1038/s41598-017-05126-1, 2017. [Link]
  11. Takeshi Iwase, Kentaro Yamamoto, Kosei Yanagida, Eimei Ra, Yasuki Ito, Kenta Murotani and Hiroko Terasaki
    Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
    Scientific Reports, 7(1), 13878, doi:10.1038/s41598-017-14118-0, 2017. [Link]
  12. Yuji Mikoshiba, Takeshi Iwase, Yoshitaka Ueno, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
    A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation
    Scientific Reports, 8(1), 14128, doi:10.1038/s41598-018-32487-y, 2018. [Link]
  13. Takeshi Iwase, Tomohiko Akahori, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
    Evaluation of optic nerve head blood flow in response to increase of intraocular pressure
    Scientific Reports, 8(1), 17235, doi:10.1038/s41598-018-35683-y, 2018. [Link]
  14. Iwase Takeshi, Mikoshiba Yuji, Ra Eimei, Yamamoto Kentaro, Ueno Yoshitaka, Terasaki Hiroko
    Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation
    Medicine, 98(24), e16062, Jun 2019. doi:10.1097/MD.0000000000016062 [Link]
  15. Fumi Kuroda, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
    Correlation between blood flow on optic nerve head and structural and functional changes in eyes with glaucoma
    Scientific Reports, 10, 729, doi:10.1038/s41598-020-57583-w, 2020. [Link]
  16. Ryo Tomita, Takeshi Iwase, Yoshitaka Ueno, Kensuke Goto, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
    Differences in Blood Flow Between Superior and Inferior Retinal Hemispheres
    Investigative Ophthalmology and Visual Science, 61(5), 27, doi:10.1167/iovs.61.5.27, 2020. [Link]
  17. Yoshitaka Ueno, Takeshi Iwase, Kensuke Goto, Ryo Tomita, Eimei Ra, Kentaro Yamamoto and Hiroko Terasaki
    Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
    Scientific Reports, 11(1), 1-12, doi:10.1038/s41598-021-84067-2, 2021. [Link]
  18. Ryo Tomita, Takeshi Iwase, Marie Fukami, Kensuke Goto, Eimei Ra and Hiroko Terasaki
    Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
    Scientific Reports, 11(1), 1-11, 10.1038/s41598-021-99572-7, 2021. doi:10.1038/s41598-021-99572-7 [Link]
  19. Chie Iwase, Takeshi Iwase, Ryo Tomita, Tomohiko Akahori, Eimei Ra, Kentaro Yamamoto and Hiroko Terasaki
    Changes in pulse waveforms in response to intraocular pressure elevation determined by laser speckle flowgraphy in healthy subjects
    BMC Ophthalmology, 21(1), 1-13, doi:10.1186/s12886-021-02070-7, 2021. [Link]
  20. Etsuyo Horiguchi, Jun Takeuchi, Ryo Tomita, Keiko Asai, Yuyako Nakano, Hikaru Ota, Yosuke Taki, Yasuki Ito, Hiroko Terasaki, Koji M Nishiguchi and Keiko Kataoka
    Choroidal Hemodynamics in Central Serous Chorioretinopathy after Half-dose Photodynamic Therapy and the Effects of Smoking
    Scientific Reports, doi:10.21203/rs.3.rs-1776430/v1, 2022. [Link]
  21. Ryo Tomita, Takeshi Iwase
    Visualization of Changes in Retinal Vascular Resistance Before and After Administration of Anti-Vascular Endothelial Growth Factor for Branch Retinal Vein Occlusion
    Ophthalmic Surgery, Lasers and Imaging Retina, doi:10.3928/23258160-20230809-01, 2023. [Link]
  22. Yasuda Sayuri, Takai Yoshiko, Yasuda Yuma, Yamamoto Takanori, Tomita Ryo, Iwase Takeshi, Nonobe Norie, Takeuchi Jun, Kojima Taiki, Nishiguchi Koji M., Kaneko Hiroki
    Quantitative Evaluation of Changes in Retinal and Choroidal Blood Flow Following Strabismus Surgery
    Trans. Vis. Sci. Tech., 14(3), 12, Mar 2025. doi:10.1167/tvst.14.3.12 [Link]

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Department of Ophthalmology, Osaka Medical and Pharmaceutical University

  1. S.Kojima, T. Sugiyama, M. Toda, H. Oku, K. Shimizu, O. Ishida, M. Nakajima and I. Azuma
    Effect of nitric oxide on rabbit optic nerve head circulation
    Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995.
  2. Okuno T, Sugiyama T, Ikeda T
    Correlation between Heidelberg Retina Flowmeter HRF and laser speckle flowgrafy LSFG
    Invest Ophthalmol Vis Sci 2001;42:S84.
  3. Okuno T, Sugiyama T, Kojima S, Nakajima M, Ikeda T
    Diurnal variation in microcirculation of ocular fundus and visual field change in normal-tension glaucoma
    Eye, 18(7), 697-702, Jul 2004. doi:10.1038/sj.eye.6700749 [Link]
  4. Okuno T, Sugiyama T, Kohyama M, Kojima S, Oku H, Ikeda T
    Ocularblood flow changes after dynamic exercise in humans
    Eye. 2006 Jul;20(7):796-800. Epub 2005 Jul 8.
  5. Sugiyama T, Oku H, Komori A, et al
    Effect of P2X7 receptor activation on the retinal blood velocity of diabetic rabbits
    Arch Ophthalmol 124:1143-1149,2006 doi:10.1001/archopht.124.8.1143 [Link]
  6. Sugiyama T, Kojima S, Ishida O, Ikeda T
    Changes in optic nerve head blood flow induced by the combined therapy of latanoprost and beta blockers.
    Acta Ophthalmol 2008 Dec 2. doi:10.1111/j.1755-3768.2008.01460.x [Link]
  7. Sugiyama T, Mashima Y, Yoshioka Y, Oku H, Ikeda T
    Effect of unoprostone on topographic and blood flow changes in the ischemic optic nerve head of rabbits.
    Arch Ophthalmol 127(4):454-9,2009 doi:10.1001/archophthalmol.2008.606 [Link]
  8. Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S
    Use of laser speckle flowgraphy in ocular blood flow research.
    Acta Ophthalmol. :2009 Sep 2. doi:10.1111/j.1755-3768.2009.01586.x [Link]
  9. Tetsuya Sugiyama, Maho Shibata, Sumiko Kajiura, Takashi Okuno, Masahiro Tonari, Hidehiro Oku and Tsunehiko Ikeda
    Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.
    Investigative ophthalmology & visual science, 52(1): 64-69, 2011. doi:10.1167/iovs.10-5265 [Link]
  10. Shibata M, Oku H, Sugiyama T, Kobayashi T, Tsujimoto M, Okuno T, Ikeda T.
    Disruption of Gap Junctions May Be Involved in Impairment of Autoregulation in Optic Nerve Head Blood Flow of Diabetic Rabbits
    IOVS 2011; 52: 2152-2159. doi:10.1167/iovs.10-6605 [Link]
  11. Maho Shibata, Tetsuya Sugiyama, Masaaki Hoshiga, Junko Hotchi, Takashi Okuno, Hidehiro Oku, Toshiaki Hanafusa and Tsunehiko Ikeda
    Changes in optic nerve head blood flow, visual function, and retinal histology in hypercholesterolemic rabbits
    Experimental Eye Research, 93(6), 818-824, 2011. doi:10.1016/j.exer.2011.09.014 [Link]
  12. Maho Shibata, Tetsuya Sugiyama, Takuji Kurimoto,Hidehiro Oku, Takashi Okuno, Takatoshi Kobayashi ,Tsunehiko Ikeda
    Involvement of Glial Cells in the Autoregulation of Optic Nerve Head Blood Flow in Rabbits
    IOVS 2012; 53: doi: 10.1167/iovs.11-9316 [Link]
  13. Ryohsuke Kohmoto, Tetsuya Sugiyama, Shota Kojima, Mari Ueki and Tsunehiko Ikeda
    Optic Nerve Head Blood Flow Changes Induced by Ripasudil Added to Prostaglandin Analogues in Primary Open Angle Glaucoma
    EC Ophthalmology, 4(6), 640-647, 2017.
  14. Teruyo Kida, Josef Flammer, Hidehiro Oku, Katarzyna Konieczka, Seita Morishita, Taeko Horie and Tsunehiko Ikeda
    Vasoactivity of retinal veins: A potential involvement of endothelin-1 (ET-1) in the pathogenesis of retinal vein occlusion (RVO).
    Experimental Eye Research, doi:10.1016/j.exer.2018.07.016, 2018. [Link]
  15. Teruyo Kida, Josef Flammer, Hidehiro Oku, Katarzyna Konieczka, Seita Morishita, Taeko Horie and Tsunehiko Ikeda
    Data on the involvement of endothelin-1 (ET-1) in the dysregulation of retinal veins
    Data in Brief, doi:10.1016/j.dib.2018.09.070, 2018. [Link]
  16. Mari Ueki, Tetsuya Sugiyama, Ryohsuke Kohmoto, Shota Kojima, Michiko Maeda, Emika Nemoto, Satoru Tokuoka and Tsunehiko Ikeda
    Blood Flow in the Optic Nerve Head Changes after Disc Hemorrhage in Primary Open Angle Glaucoma
    EC Ophthalmology, 10(3), 230-235, 2019.
  17. Ryohsuke Kohmoto, Tetsuya Sugiyama, Mari Ueki, Shota Kojima, Michiko Maeda, Emika Nemoto, Satoru Tokuoka and Tsunehiko Ikeda
    Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes
    Clinical Ophthalmology, 13, 1799-1805, 2019. doi:10.2147/opth.s213031 [Link]
  18. Masashi Mimura, Yuko Nishikawa, Keiko Inagaki, Yohei Sato, Yasushi Fujita and Don O Kikkawa
    Change of intraocular blood flow during treatment for thyroid eye disease
    Taiwan Journal of Ophthalmology, 12(1), 97, doi:10.4103/tjo.tjo_2_22, 2022. [Link]

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Nakano Eye Clinic

  1. Tetsuya Sugiyama
    Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases
    Photonics, 1, no.3, 220-234, 2014. doi:10.3390/photonics1030220 [Link]
  2. Tetsuya Sugiyama, Hajime Nakamura, Emiko Shimizu, Kazuaki Miyamoto and Ryozo Yamada
    Clinical Usefulness of the Measurement of Optic Nerve Head Blood Flow in Myopic Normal-Tension Glaucoma
    International Journal of Ophthalmic Research 2015 June 1(1): 11-18 doi:10.17554/j.issn.2409-5680.2015.01.1 [Link]
  3. Tetsuya Sugiyama
    Coexisting Normal-Tension Glaucoma and Deficiencies of Folic Acid and Vitamin B6 (Pyridoxal)
    International Journal of Ophthalmology and Clinical Research, 2(4):037, 2015. doi:10.23937/2378-346x/1410037 [Link]
  4. Tetsuya Sugiyama and Hajime Nakamura
    Increased Short-Term Fluctuation in Optic Nerve Head Blood Flow in a Case of Normal-Tension Glaucoma by the Use of Laser Speckle Flowgraphy.
    Vision 2016, 1, 5. doi:10.3390/vision1010005 [Link]
  5. Tetsuya Sugiyama, Emiko Shimizu and Kazuaki Miyamoto
    Ocular Blood Flow Changes in a Case with Nonarteritic Ischemic Optic Neuropathy Complicated by Obstructive Sleep Apnea Syndrome
    EC Ophthalmology, 9.6, 361-367, 2018.

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Tane Memorial Eye Hospital

  1. R.Tano, M.Sakamoto, M.Ikeda, S.Sugita, H.Fujii, T.Mano, T.Maeno
    Analysis of Retinal Blood Flow by Laser Speckle Flowgraphy in a Case With Central Retinal Vein Occlusion After Radial Optic Neurotomy
    ARVO, 2008, (4274/A367)
  2. T.Maeno, R.Tano, M.Sakamoto, N.Onishi, K.Kakurai, T.Yamada, H.Fujii, T.Mano
    Measurement of Retinal Blood Flow Volume by Laser Speckle Flowgraphy Before and After Arteriovenous Sheathotomy for Branch Retinal Vein Occlusion
    ARVO, 2008, (4265/A358) doi:10.1201/9780203734315-39 [Link]

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National Cerebral and Cardiovascular Center

  1. Junichi Shimamura, Tomohiro Nishinaka, Toshihide Mizuno, Tomonori Tsukiya, Ayako Inatomi, Futoshi Kobayashi, Nobumasa Katagiri, Yoshiaki Takewa, Takashi Nishimura and Eisuke Tatsumi
    Assessment of ocular blood flow in continuous-flow ventricular assist device by laser speckle flowgraphy
    Journal of Artificial Organs, 1-6, doi:10.1007/s10047-021-01265-5, 2021. [Link]

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Department of Ophthalmology, Kyoto University

  1. Yoshimasa Kuroda, Akihito Uji and Nagahisa Yoshimura
    Factors associated with optic nerve head blood flow and color tone: a retrospective observational study.
    Graefe's Archive for Clinical and Experimental Ophthalmology, 1-8, 2016. doi:10.1007/s00417-015-3247-0 [Link]

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Department of Ophthalmology, Saneikai Tsukazaki Hospital

  1. Daisuke Nagasato, Yoshinori Mitamura, Kentaro Semba, Kei Akaiwa, Toshihiko Nagasawa, Yuki Yoshizumi, Hitoshi Tabuchi and Yoshiaki Kiuchi
    Correlation between optic nerve head circulation and visual function before and after anti-VEGF therapy for central retinal vein occlusion: prospective, interventional case series
    BMC ophthalmology, 16(1), doi:10.1186/s12886-016-0211-7, 2016. [Link]
  2. Daisuke Nagasato, Yoshinori Mitamura, Mariko Egawa, Masahiro Kameoka, Toshihiko Nagasawa, Hitoshi Tabuchi, Takamasa Kinoshita, Shozo Sonoda and Taiji Sakamoto
    Changes of choroidal structure and circulation after water drinking test in normal eyes
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04427-7, 2019. [Link]
  3. Daisuke Nagasato, Yoshinori Mitamura, Mariko Egawa, Fumiko Murao, Toshihiko Nagasawa, Natsumi Komori, Shozo Sonoda, Taiji Sakamoto and Hitoshi Tabuchi
    Changes in Choroidal Component Ratio and Circulation After Coffee Intake in Healthy Subjects.
    Investigative Ophthalmology & Visual Science, 62(3), 27-27, doi:10.1167/iovs.62.3.27, 2021. [Link]

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Department of Ophthalmology, Nara Medical University

  1. Okamoto M, Matsuura T, Ogata N
    Ocular blood flow before, during, and after vitrectomy determined by laser speckle flowgraphy.
    Ophthalmic Surg Lasers Imaging Retina. 2014 Mar 1;45(2):118-24. doi: 10.3928/23258160-20140306-04. [Link]
  2. Masahiro Okamoto, Toyoaki Matsuura and Nahoko Ogata
    EFFECTS OF PANRETINAL PHOTOCOAGULATION ON CHOROIDAL THICKNESS AND CHOROIDAL BLOOD FLOW IN PATIENTS WITH SEVERE NONPROLIFERATIVE DIABETIC RETINOPATHY.
    RETINA, 36(4), 805-811, 2016. doi:10.1097/iae.0000000000000800 [Link]
  3. Masahiro Okamoto, Mariko Yamashita and Nahoko Ogata
    Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema
    Graefe's Archive for Clinical and Experimental Ophthalmology, 1-8, doi: 10.1007/s00417-018-3939-3, 2018. [Link]

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Department of Anesthesiology, Nara Medical University

  1. Hayashi Hironobu, Okamoto Masahiro, Kawanishi Hideaki, Matsuura Toyoaki, Tabayashi Nobuoki, Taniguchi Shigeki, Kawaguchi Masahiko
    Ocular Blood Flow Measured Using Laser Speckle Flowgraphy During Aortic Arch Surgery With Antegrade Selective Cerebral Perfusion
    Journal of Cardiothoracic and Vascular Anesthesia, 30(3), 613-618, Jun 2016. doi:10.1053/j.jvca.2016.01.021 [Link]
  2. Hironobu Hayashi, Masahiro Okamoto, Hideaki Kawanishi, Nobuoki Tabayashi, Toyoaki Matsuura, Shigeki Taniguchi and Masahiko Kawaguchi
    Association between optic nerve head blood flow measured by laser speckle flowgraphy and radial arterial pressure during aortic arch surgery.
    Journal of Cardiothoracic and Vascular Anesthesia, 2017. doi:10.1053/j.jvca.2017.08.001 [Link]
  3. Ayako Oi, Hironobu Hayashi, Yasushi Motoyama, Hideaki Kawanishi, Ichiro Nakagawa, Hiroyuki Nakase and Masahiko Kawaguchi
    Application of laser speckle flowgraphy to evaluate cerebral perfusion after carotid endarterectomy
    Heliyon, 9(3), e14400, doi:10.1016/j.heliyon.2023.e14400, 2023. [Link]

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Department of Neurosurgery, Nara Medical University

  1. Yasushi Motoyama, Hironobu Hayashi, Hideaki Kawanishi, Kohsuke Tsubaki, Tsunenori Takatani, Yoshiaki Takamura, Masashi Kotsugi, Taekyun Kim, Shuichi Yamada, Ichiro Nakagawa, Young-Su Park, Masahiko Kawaguchi and Hiroyuki Nakase
    Ocular blood flow by laser speckle flowgraphy to detect cerebral ischemia during carotid endarterectomy
    Journal of Clinical Monitoring and Computing, doi: 10.1007/s10877-020-00475-1, 2020. [Link]

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Department of Ophthalmology, Hiroshima University

  1. Kazuyuki Hirooka, Kenji Oki, Keiko Ogawa-Ochiai, Yuta Nakaniida, Hiromitsu Onoe and Yoshiaki Kiuchi
    Blood flow in the optic nerve head in patients with primary aldosteronism
    PLOS ONE, 18(4), e0285039, doi:10.1371/journal.pone.0285039, 2023. [Link]

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Department of Ophthalmology, Tokushima University

  1. Takamasa Kinoshita , Junya Mori, Natsuki Okuda, Hiroko Imaizumi, Masanori Iwasaki, Miho Shimizu, Hirotomo Miyamoto, Kei Akaiwa, Kentaro Semba, Shozo Sonoda, Taiji Sakamoto and Yoshinori Mitamura
    Effects of Exercise on the Structure and Circulation of Choroid in Normal Eyes.
    PLOS ONE, 11(12), e0168336, 2016. doi:10.1371/journal.pone.0168336 [Link]

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Department of Ophthalmology, Kagawa University

  1. Yuki Nakano, Yukiko Myoshi, Yuta Koyama, Rie Osaka and Kiyoshi Suzuma
    Retinal oxygen saturation and retinal vascular resistance before and after treatment for central retinal vein occlusion (CRVO)
    Investigative Ophthalmology and Visual Science, 64(8), 1774, 2023 ARVO Annual Meeting abstract, 2023.
  2. Yuta Koyama, Yukiko Myoshi, Rie Osaka, Yuki Nakano, Ayaka Hara and Kiyoshi Suzuma
    Comparison of retinal blood flow and vascular resistance between diabetic macular edema and normal eyes
    Investigative Ophthalmology and Visual Science, 64(8), 2638, 2023 ARVO Annual Meeting abstract, 2023.
  3. Takeru Shimazaki, Eri Nitta, Nobuko Kobayashi, Hirokazu Kojima and Kiyoshi Suzuma
    Effects of trabeculectomy on blood flow and waveform changes of laser speckle flowgraphy in open angle glaucoma
    Investigative Ophthalmology and Visual Science, 64(8), 4716, 2023 ARVO Annual Meeting abstract, 2023.
  4. Kojima Hirokazu, Yamashita Ayana, Nakano Yuki, Booka Aki, Tatara Yusuke, Yamada Takeyasu, Akimitsu Junichiro, Miyoshi Yukiko, Osaka Rie, Suzuma Kiyoshi
    Significant Correlation Between Choroidal Thickness and Decrease in Choroidal Blood Flow After Switching to Brolucizumab for Refractory Neovascular Age-Related Macular Degeneration
    Ophthalmol Ther, 15(1), 393-402, Jan 2026. doi:10.1007/s40123-025-01279-9 [Link]

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Department of Ophthalmology, Kyushu University

  1. Hiroshi Enaida, Kenji Okamoto, Hitoshi Fujii and Tatsuro Ishibashi
    LSFG Findings of Proliferative Diabetic Retinopathy After Intravitreal Injection of Bevacizumab
    Ophthalmic Surgery, Lasers and Imaging 41 Online(): e1-e3, 2010. doi:10.3928/15428877-20101124-11 [Link]
  2. Masato Akiyama, Yasuhiro Ikeda, Noriko Yoshida, Shoji Notomi, Yusuke Murakami, Toshio Hisatomi, Hiroshi Enaida, Tatsuro Ishibashi
    Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa
    Acta Ophthalmologica, DOI: 10.1111/aos.12293, 2013. [Link]
  3. Yusuke Murakami, Yasuhiro Ikeda, Masato Akiyama, Kota Fujiwara, Noriko Yoshida, Shunji Nakatake, Shoji Notomi, Takahiro Nabeshima, Toshio Hisatomi, Hiroshi Enaida and Tatsuro Ishibashi
    Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa.
    Acta Ophthalmologica, DOI: 10.1111/aos.12693, 2015. [Link]
  4. Yusuke Murakami, Jun Funatsu, Shunji Nakatake, Kohta Fujiwara, Takashi Tachibana, Yoshito Koyanagi, Toshio Hisatomi, Shigeo Yoshida, Shozo Sonoda, Taiji Sakamoto, Koh-Hei Sonoda and Yasuhiro Ikeda
    Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa
    Investigative Ophthalmology & Visual Science, 59(2), 1134-1143, 2018. doi:10.1167/iovs.17-23050 [Link]

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Institute of Health Science, Kyushu University

  1. Hayashi N, Ikemura T, Someya N
    Effects of dynamic exercise and its intensity on ocular blood flow in humans.
    Eur J Appl Physiol. 2011 doi:10.1007/s00421-011-1880-9 [Link]
  2. Hideaki Kashima, Naoyuki Hayashi
    Basic Taste Stimuli Elicit Unique Responses in Facial Skin Blood Flow
    PLOS ONE 6(12) 2011: e28236. doi:10.1371/journal.pone.0028236 [Link]
  3. Naoyuki Hayashi, Tsukasa Ikemura, Nami Someya
    Changes in ocular flow induced by hypo- and hypercapnia relate to static visual acuity in humans
    Eye Reports 2011, volume.1:e8, Page.20-24
    doi:10.4081/eye.2011.e8 [Link]
  4. Ikemura T, Someya N, Hayashi N
    Autoregulation in the ocular and cerebral arteries during the cold pressor test and handgrip exercise.
    Eur J Appl Physiol.  2011 doi:10.1007/s00421-011-2016-y [Link]
  5. Tsukasa Ikemura, Naoyuki Hayashi
    Ocular circulatory responses to exhaustive exercise in humans
    Eur J Appl Physiol. 2012 doi:10.1007/s00421-012-2313-0 [Link]
  6. Kashima Hideaki, Hayashi Naoyuki
    Facial skin blood flow responses to irritant stimuli in the oral cavity
    Autonomic Neuroscience, 174(1-2), 61-65, Mar 2013. doi:10.1016/j.autneu.2012.11.010 [Link]

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Department of Ophthalmology, University of Occupational and Environmental Health

  1. K.Nagaya, H. Takahashi, H. Fujii
    Optic nerve head microcirculation using laser speckle flowgraphy in patients with normal tension glaucoma
    ARVO, 1999, #1457/B365

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Yamana Eye Hospital

  1. Y.Yamana, M. Matsuo, N. Konishi and H. Fujii
    Heidelberg Retina Flowmeter and Laser Speckle Flowgraphy System: a comparative evaluation
    Microcirculation Annual, 13, 195-196, 1997.
  2. Y.Yamana, M. Matsuo, N. Konishi and H. Fujii
    Peripapillary tissue, retinal vessels and optic nerve head blood flow rates using laser speckle flowgraphy
    20th European Conference on Microcirculation, 219-223, 1998.
  3. Y.Yamana, M. Matsuo, K. Goya, N. Konishi and H. Fujii
    Retinal Vessels and Peripapillary Tissue Blood Flow in Diabetes Using Laser Speckle Flowgraphy System: a comparative evaluation
    Microcirculation Annual, 15,117-118, 1999.
  4. Y.Yamana, M. Matsuo, Y. Koketu, K. Goya, M. Wakisaka, M. Iwase, M.Yoshinari, N. Konishi, H. Fujii
    Effect Acute Hyperglycemia on Chorio-Retinal Blood Flow in IGT and Diabetes Mellitus
    Microcirculation Annual, 18, 85-86, 2002
  5. Y.Yamana, M. Matsuo, Y. Koketsu, K. Goya, M. Yoshinari, N. Konishi, H.Fujii
    Dysregulation of the Postprandial Retinal Blood Flpw in Type 2 Diabetes
    European Society for Microcirculation, 18,95-98, 2002

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Department of Orthoptics, Fukuoka International University of Health and Welfare

  1. Mayumi Haneda, Yuki Hashimoto, Airi Mishima, Daichi Saito and Takeshi Yoshitomi
    Changes in choroidal circulation hemodynamics during the menstrual cycle in young, healthy women
    PLOS ONE, 17(6), e0270501, doi:10.1371/journal.pone.0270501, 2022. [Link]
  2. Sakurako Imabayashi, Yuki Hashimoto, Yumi Ishimaru, Rino Umemoto, Miho Chiyozono, Toshitaka Yamanokuchi and Takeshi Yoshitomi
    Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants
    Tomography, 9(2), 790-797, doi:10.3390/tomography9020064, 2023. [Link]
  3. Kuwahara Fuka, Hashimoto Yuki, Toh Natsumi, Imabayashi Sakurako, Sakamoto Ami, Shiraishi Kanon, Igawa Rena, Yoshitomi Takeshi
    Parasympathetic Dominance Decreases the Choroidal Blood Flow Velocity Measured Using Laser Speckle Flowgraphy
    Cureus, Oct 2023. doi:10.7759/cureus.46996 [Link]

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Department of Ophthalmology, Kurume University School of Medicine

  1. Nobuhiro Kato, Masatoshi Haruta, Kei Furushima, Rikki Arai, Yu Matsuo and Shigeo Yoshida
    Decrease in Ocular Blood Flow Thirty Minutes After Intravitreal Injections of Brolucizumab and Aflibercept for Neovascular Age-Related Macular Degeneration
    Clinical Ophthalmology, 2023(17), 1187-1192, doi:10.2147/OPTH.S407249, 2023. [Link]
  2. Kato Nobuhiro, Haruta Masatoshi, Arai Rikki, Nagae Akito, Sato Kazunori, Furushima Kei, Yoshida Shigeo
    Association of Molar Dose and Early Retinochoroidal Blood Flow Changes After Intravitreal Anti-Vascular Endothelial Growth Factor Therapy
    Invest. Ophthalmol. Vis. Sci., 66(15), 56, Dec 2025. doi:10.1167/iovs.66.15.56 [Link]

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Department of Ophthalmology, Saga University

  1. Hiroshi Enaida, Shinji Nagata, Atsunobu Takeda, Shintaro Nakao, Yasuhiro Ikeda and Tatsuro Ishibashi
    Changes in chorioretinal blood flow velocity and cerebral blood flow after carotid endarterectomy
    Japanese Journal of Ophthalmology, 1-7, doi:10.1007/s10384-016-0472-y, 2016. [Link]
  2. Hiroaki Sakai, Kosuke Kawata, Jun Masuoka, Tomohisa Nishimura and Hiroshi Enaida
    Diagnosis and clinical course of ocular ischemic syndrome with retinal vascular abnormalities due to unilateral ocular artery and internal carotid artery stenosis in a child with neurofibromatosis type 1: a case report
    BMC Ophthalmology, 20(1), 426, doi:10.1186/s12886-020-01670-z, 2020. [Link]

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Department of Ophthalmology, Nagasaki University

  1. Matsumoto Makiko, Suzuma Kiyoshi, Fukazawa Yoshiko, Yamada Yoshihisa, Tsuiki Eiko, Fujikawa Azusa and Kitaoka Takashi
    Retinal blood flow levels measured by Laser Speckle Flowgraphy in patients who received intravitreal bevacizumab injection for macular edema secondary to central retinal vein occlusion.
    Retinal Cases and Brief Reports, 8(1), 60-66, 2014. doi:10.1097/icb.0000000000000005 [Link]
  2. Y.Yamada, K.Suzuma, M.Matsumoto, E.Tsuiki, A.Fujikawa, T.Harada and T.Kitaoka
    Retinal Blood Flow Correlates to Aqueous Vascular Endothelial Growth Factor in Central Retinal Vein Occlusion.
    RETINA, 35(10), 2037-2042, 2015. doi:10.1097/iae.0000000000000595 [Link]
  3. Makiko Matsumoto, Kiyoshi Suzuma, Yoshihisa Yamada, Eiko Tsuiki, Azusa Fujikawa and Takashi Kitaoka
    Retinal blood flow after intravitreal bevacizumab is a predictive factor for outcomes of macular edema associated with central retinal vein occlusion.
    Retina, doi:10.1097/IAE.0000000000001531, 2017. [Link]
  4. Yamada Yoshihisa, Suzuma Kiyoshi, Onizuka Naoko, Uematsu Masafumi, Mohamed Yasser Helmy, Kitaoka Takashi
    Evaluation of retinal blood flow before and after panretinal photocoagulation using pattern scan laser for diabetic retinopathy
    Current Eye Research, 42(12), 1707-1712, Dec 2017. doi:10.1080/02713683.2017.1358373 [Link]
  5. Makiko Matsumoto, Kiyoshi Suzuma, Fumito Akiyama, Kanako Yamada, Shiori Harada, Eiko Tsuiki and Takashi Kitaoka
    Retinal Microvascular Resistance Estimated from Waveform Analysis Is Significantly Higher With a Threshold Value in Central Retinal Vein Occlusion
    Translational Vision Science and Technology, 9(11), 4, doi:10.1167/tvst.9.11.4, 2020. [Link]
  6. Makiko Matsumoto, Kiyoshi Suzuma, Fumito Akiyama, Kanako Yamada, Shiori Harada, Eiko Tsuiki and Takashi Kitaoka
    Retinal Vascular Resistance Significantly Correlates With Visual Acuity After 1 Year of Anti-VEGF Therapy in Central Retinal Vein Occlusion
    Translational Vision Science and Technology, 10(11), 19, doi:10.1167/tvst.10.11.19, 2021. [Link]

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Department of Ophthalmology, University of Miyazaki

  1. Tomoyuki Maekubo, Hideki Chuman, Nobuhisa Nao-i
    Laser speckle flowgraphy for differentiating between nonarteritic ischemic optic neuropathy and anterior optic neuritis
    Jpn. J. Ophthalmol., May 2013, (doi:10.1007/s10384-013-0246-8) [Link]
  2. Takako Hidaka, Hideki Chuman and Nobuhisa Nao-I
    Evaluation of optic nerve head blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy using laser speckle flowgraphy
    Graefe's Archive for Clinical and Experimental Ophthalmology, 255(10), 1973-1980, 2017. doi:10.1007/s00417-017-3753-3 [Link]
  3. Hideki Chuman, Takako Sugimoto and Nobuhisa Nao-I
    Vasodilatory effect of L-arginine on isolated rabbit and human posterior ciliary arteries in vitro and increased optic disc blood flow in vivo.
    Graefe's Archive for Clinical and Experimental Ophthalmology, 255(12), 2381-2388, 2017. doi:10.1007/s00417-017-3824-5 [Link]

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Devers Eye Institute, Legacy Health

  1. Y.Liang, L. Wang, G. Cull, H. Fujii, J.C. Downs.
    Systemic Blood Pressure Determines the Magnitude of IOP-Induced Blood Flow Change in the Optic Nerve Head of Non-Human Primate
    ARVO, 2008, (3265)
  2. Yi Liang, J. Crawford Downs, Brad Fortune, Grant Cull, George A. Cioffi, Lin Wang
    Impact of Systemic Blood Pressure on the Relationship between Intraocular Pressure and Blood Flow in the Optic Nerve Head of Nonhuman Primates
    IOVS, 50:2154-2160, May 2009 doi:10.1167/iovs.08-2882 [Link]
  3. Yi Liang, Brad Fortune, Grant Cull, George A. Cioffi, Lin Wang
    Quantification of dynamic blood flow autoregulation in Optic nerve head of rhesus monkeys
    Experimental Eye Research, 90, no.2: 203-209, 2010. doi:10.1016/j.exer.2009.10.009 [Link]
  4. Lin Wang, Grant A. Cull, Chelsea Piper, Claude F. Burgoyne, Brad Fortune
    Anterior and Posterior Optic Nerve Head Blood Flow in Nonhuman Primate Experimental Glaucoma Model Measured by Laser Speckle Imaging Technique and Microsphere Method
    IOVS, November 20, 2012 IOVS-12-10911 doi:10.1167/iovs.12-10911 [Link]
  5. Chelsea Piper, Brad Fortune, Grant Cull, George A. Cioffi and Lin Wang
    BASAL BLOOD FLOW AND AUTOREGULATION CHANGES IN THE OPTIC NERVE OF RHESUS MONKEYS WITH IDIOPATHIC BILATERAL OPTIC ATROPHY
    IOVS, January 3, 2013 IOVS-12-9773 doi:10.1167/iovs.12-9773 [Link]
  6. Grant Cull, Claude F. Burgoyne, Brad Fortune and Lin Wang
    Longitudinal Hemodynamic Changes within the Optic Nerve Head in Experimental Glaucoma
    IOVS, June 4, 2013 IOVS-13-12013 doi:10.1167/iovs.13-12013 [Link]
  7. Lin Wang, Claude F. Burgoyne, Grant Cull, Simmon Thompson and Brad Fortune
    Static Blood flow Autoregulation in the Optic Nerve Head in Normal and Experimental Glaucoma
    IOVS, January 16, 2014 IOVS-13-13716 doi:10.1167/iovs.13-13716 [Link]
  8. Jintao Yu, Yi Liang, Simon Thompson, Grant Cull, Lin Wang
    Parametric transfer function analysis and modeling of blood flow autoregulation in the optic nerve head
    Int J Physiol Pathophysiol Pharmacol 2014;6(1):13-22
  9. Lin Wang, Grant Cull, Claude F. Burgoyne, Simon Thompson and Brad Fortune
    Longitudinal Alterations in the Dynamic Autoregulation of Optic Nerve Head Blood Flow Revealed in Experimental Glaucoma
    IOVS, May 8, 2014 IOVS-14-14020. doi:10.1167/iovs.14-14020 [Link]
  10. Lin Wang, Grant A. Cull and Brad Fortune
    Optic Nerve Head Blood Flow Response to Reduced Ocular Perfusion Pressure by Alteration of Either the Blood Pressure or Intraocular Pressure
    Current Eye Research, Posted online on June 9, 2014. (doi:10.3109/02713683.2014.924146) [Link]
  11. Grant Cull, Reinhard Told, Claude F. Burgoyne, Simon Thompson, Brad Fortune and Lin Wang
    Compromised Optic Nerve Blood Flow and Autoregulation Secondary to Neural DegenerationHemodynamics Secondary to Optic Nerve Degeneration.
    IOVS, 56(12), 7286-7292, 2015. doi:10.1167/iovs.15-17879 [Link]
  12. Fan Ning, Wang Pei, Tang Li, Liu Xuyang
    Ocular Blood Flow and Normal Tension Glaucoma
    BioMed Research International, 2015, 1-7, 2015. doi:10.1155/2015/308505 [Link]
  13. Stuart K. Gardiner, Grant Cull, Brad Fortune and Lin Wang
    Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma
    IOVS, 60(8), 3110-3118, doi:10.1167/iovs.19-27389, 2019. [Link]
  14. Stuart Keith Gardiner, Grant Cull, Juan Reynaud, Steven L Mansberger, Brad Fortune and Lin Wang
    The relation between blood flow within the remaining peripapillary vasculature and functional progression in glaucoma
    Investigative Ophthalmology & Visual Science, 61(7), 620, 2020.
  15. Grant Cull, Crystal Jadach, Juan Reynaud, Kristine Ly, Michaela Dunn, Dawn Jennings, Trinity Holthausen, Howard Lockwood, Stuart Keith Gardiner, Lin Wang, Jennifer Wilk and Brad Fortune
    Pharmacodynamic response of optic nerve head (ONH) tissue blood flow measured by laser speckle flowgraphy (LSFG) after administration of PER-001, an endothelin receptor antagonist
    Investigative Ophthalmology and Visual Science, 63(7), 4029-A0414, 2022 ARVO Annual Meeting abstract, 2022.
  16. Stuart K. Gardiner, Grant Cull, Brad Fortune
    Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects
    Investigative Ophthalmology and Visual Science, 64(7), 30, doi:10.1167/iovs.64.7.30, 2023. [Link]
  17. Stuart Keith Gardiner, Cindy Albert, Brad Fortune, Steven L Mansberger and Grant Cull
    Retinal vessel pulsatile characteristics can predict functional progression in glaucoma suspects
    Investigative Ophthalmology and Visual Science, 64(8), 3778, 2023 ARVO Annual Meeting abstract, 2023. doi:10.1167/iovs.64.7.30 [Link]
  18. Michaela Dunn, Grant Cull, Juan Reynaud, Dawn Jennings, Trinity Holthausen, Adriana Di Polo and Brad Fortune
    Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage
    Translational Vision Science and Technology, 12(8), 16, doi:10.1167/tvst.12.8.16, 2023. [Link]
  19. Higgins Bethany E., Cull Grant, Gardiner Stuart K.
    Assessment of Time Lag Between Blood Flow, Retinal Nerve Fiber Layer Thickness and Visual Field Sensitivity Changes in Glaucoma
    Invest. Ophthalmol. Vis. Sci., 65(4), 7, Apr 2024. doi:10.1167/iovs.65.4.7 [Link]
  20. Gardiner Stuart K., Reynaud Juan, Cull Grant, Yang Hongli, Mansberger Steven L., Fortune Brad
    Relations Between Pulsatility in the Optic Nerve Head or Peripapillary Retinal Vessels and the Rate of Progression in Glaucoma
    Invest. Ophthalmol. Vis. Sci., 66(12), 34, Sep 2025. doi:10.1167/iovs.66.12.34 [Link]
  21. Dunn Michaela, Cull Grant, Reynaud Juan, Gardiner Stuart K., Di Polo Adriana, Fortune Brad
    Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma
    Invest. Ophthalmol. Vis. Sci., 67(2), 24, Feb 2026. doi:10.1167/iovs.67.2.24 [Link]

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Department of Veterinary Medicine and Surgery, University of Missouri

  1. Shyam S. Chaurasia, Rayne R. Lim, Bhav H. Parikh, Yeo Sia Wey, Bo Bo Tun, Tien Yin Wong, Chi D. Luu, Rupesh Agrawal, Arkasubhra Ghosh, Alessandra Mortellaro, Elizabeth Rackoczy, Rajiv R. Mohan and Veluchamy A. Barathi
    The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy
    Scientific reports, 8(1), 2847, doi:10.1038/s41598-018-21198-z, 2018. [Link]

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Department of Ophthalmology and Visual Sciences, University of Iowa

  1. Sophia M Chung, Zaidoon Al-Share, Matthew J. Thurtell, Ryuya Hashimoto and Randy Kardon
    Blood Flow in the Optic Nerve and Peripapillary Choroid Correlate Over Time in NAION
    Investigative Ophthalmology & Visual Science, 61(7), 804, 2020.
  2. Ryuya Hashimoto, Zaidoon Al-Share, Nitsan Duvdevan-Strier, Jan M Full, Julie Nellis and Randy Kardon
    Autoregulation of Blood Flow in the Human Retina, Optic Nerve, and Choroid in Response to Acute Decrease in Intraocular Pressure Using Novel Vacuum Goggles
    Investigative Ophthalmology & Visual Science, 61(7), 1735, 2020.
  3. Zaidoon Y Alshare, Ryuya Hashimoto and Randy Kardon
    Reduced Blood Flow in the Choroidal Watershed and Parapapillary Hypoperfusion Zones and Relation to Optic Disc Blood Flow
    Investigative Ophthalmology & Visual Science, 61(7), 1744, 2020.
  4. Michelle R. Tamplin, Kimberly A. Broadhurst, Anthony H. Vitale, Ryuya Hashimoto, Randy H. Kardon and Isabella M. Grumbach
    Longitudinal Testing of Retinal Blood Flow in a Mouse Model of Hypertension by Laser Speckle Flowgraphy
    Translational vision science & technology, 10(2), 16-16, doi:10.1167/tvst.10.2.16, 2021. [Link]
  5. Jui-Kai Wang, Michelle R. Tamplin, Mona K. Garvin, Isabella M. Grumbach and Randy H. Kardon
    A superpixel-histogram method to analyze retinal, optic nerve, and choroidal blood flow using laser speckle flowgraphy
    Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1203622, doi:10.1117/12.2611850, 2022. [Link]
  6. Noriyoshi Takahashi, Jui-Kai Wang, Edward F. Linton, Noor-Us-Sabah Ahmad, Julie K. Nellis, Mona K. Garvin and Randy H. Kardon
    Automated Optic Disc Finder and Segmentation Using Deep Learning for Blood Flow Studies in the Eye
    International Workshop on Ophthalmic Medical Image Analysis, 112-121, doi:10.1007/978-3-031-44013-7_12, 2023. [Link]
  7. Liu Emily, Tamplin Michelle R., Rosius Jurnie, Tedeschi Thomas R., Gramlich Oliver W., Kardon Randy H., Grumbach Isabella M.
    Mouse model of radiation retinopathy reveals vascular and neuronal injury
    Experimental Eye Research, 238, 109729, Jan 2024. doi:10.1016/j.exer.2023.109729 [Link]
  8. Linton Edward F., Ahmad Noor-us-Sabah, Filister Riley, Wang Jui-Kai, Sohn Elliott H, Kardon Randy H.
    Laser Speckle Flowgraphy Reveals Widespread Reductions in Ocular Blood Flow in nonexudative Age-Related Macular Degeneration
    American Journal of Ophthalmology, 273, 92-106, May 2025. doi:10.1016/j.ajo.2025.01.012 [Link]

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Department of Health and Human Physiology, University of Iowa

  1. Seth W. Holwerda, Randy H. Kardon, Ryuya Hashimoto, Jan M. Full, Julie K. Nellis, Lyndsey E. DuBose, Jess G. Fiedorowicz, and Gary L. Pierce
    Aortic stiffness is associated with changes in retinal arteriole flow pulsatility mediated by local vasodilation in healthy young/middle-age adults
    Journal of Applied Physiology, doi: 10.1152/japplphysiol.00252.2020, 2020. [Link]

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Department of Radiation Oncology, University of Iowa

  1. Michelle R.Tamplin, Kimberly A.Broadhurst, Anthony H.Vitale, Ryuya Hashimoto, Randy H.Kardon and Isabella M.Grumbach
    Measuring hyperemic response to light flicker stimulus using continuous laser speckle flowgraphy in mice
    Experimental Eye Research, 216, 108952, doi:10.1016/j.exer.2022.108952, 2022. [Link]
  2. Michelle R. Tamplin, Jui‑Kai Wang, Anthony H. Vitale, Ryuya Hashimoto, Mona K. Garvin, Elaine M. Binkley, Daniel E. Hyer, John M. Buatti, H. Culver Boldt, Randy H. Kardon and Isabella M. Grumbach
    Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma
    BMC ophthalmology, 22, 285, doi:10.1186/s12886-022-02505-9, 2022. [Link]

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The University of Iowa Hospital and Clinics

  1. Matthew T Jones, Sebastian Sanchez, Rishi R Patel, Ashrita Raghuram, Jacob M Miller, Ryuya Hashimoto, Randy Kardon and Edgar A Samaniego
    Evaluation of ocular blood flow in the assessment of symptomatic carotid stenosis
    Interventional Neuroradiology, doi:10.1177/15910199231169844, 2023. [Link]
  2. Matthew T Jones, Sebastian Sanchez, Rishi R Patel, Jacob M Miller, Ashrita Raghuram, Randy Kardon and Edgar Samaniego
    Abstract Number - 255: Laser Speckle Flowgraphy As A Surrogate Marker For Symptomatic Carotid Stenosis
    Stroke: Vascular and Interventional Neurology, 3(S1), e12677, 2023.

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Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School

  1. Shashvat Chandrakant Purohit, Colin A Lemire, Brendan Seto, Keiko Yamada and Jorge G Arroyo
    Relative Retinal Blood Flow in Patients with Central Retinal Artery Occlusions
    Investigative Ophthalmology and Visual Science, 62(8), 3197, 2021 ARVO Annual Meeting abstract, 2021.
  2. Rachelle Koch, Brendan Seto, Keiko Yamada, Purva Atreay, Colin A. Lemire, Nina Hazra and Jorge G. Arroyo
    Relative Retinal Blood Flow: A Novel and Informative Measure of Unilateral Retinal Vein Occlusion Severity
    Translational Vision Science & Technology, 10(3), 15-15, doi:10.1167/tvst.10.3.15, 2021. [Link]

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The Children's Hospital of Philadelphia

  1. Robert A Avery, Tomas S Aleman, Gui-Shuang Ying, Yinxi Yu, Arielle Garcia and Moe Hein Aung
    Effect of dark adaptation and fixation lights on macular blood flow as determined by laser speckle flowgraphy
    Investigative Ophthalmology and Visual Science, 64(8), 1995, 2023 ARVO Annual Meeting abstract, 2023.

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Departments of Neurology, The Perelman School of Medicine at the University of Pennsylvania

  1. Moe H. Aung, Tomas S. Aleman, Arielle S. Garcia, Brendan McGeehan, Gui-Shuang Ying and Robert A. Avery
    Stimulus type and duration affect magnitude and evolution of flicker-induced hyperemia measured by laser speckle flowgraphy at the optic disc and peripapillary vessels
    Scientific Reports, 14, 6659, doi:10.1038/s41598-024-57263-z, 2024. [Link]

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Department of Clinical Pharmacology, Medical University of Vienna

  1. Nikolaus Luft, Piotr A. Wozniak, Gerold C. Aschinger, Klemens Fondi, Ahmed M. Bata, René M. Werkmeister, Doreen Schmidl, Katarzyna J. Witkowska, Matthias Bolz, Gerhard Garhöfer and Leopold Schmetterer
    Measurements of Retinal Perfusion Using Laser Speckle Flowgraphy and Doppler Optical Coherence Tomography
    IOVS, 57(13), 5417-5425, 2016. doi:10.1167/iovs.16-19896 [Link]
  2. P.A. Wozniak, N. Luft, G. Aschinger, K. Fondi, A.M. Bata, K.J. Witkowska, D. Schmidl, R.M. Werkmeister, M. Bolz, G. Garhöfer and L. Schmetterer
    The assessment of ocular blood flow with laser speckle flowgraphy in healthy caucasian.
    Acta Ophthalmologica, 2016, 94.S256. doi: 10.1111/j.1755-3768.2016.0391 [Link]
  3. Nikolaus Luft, Piotr A. Wozniak, Gerold C. Aschinger, Klemens Fondi, Ahmed M. Bata, René M. Werkmeister, Doreen Schmidl, Katarzyna J. Witkowska, Matthias Bolz, Gerhard Garhöfer and Leopold Schmetterer
    Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy
    PLOS ONE, 11(12), e0168190, 2016. doi:10.1371/journal.pone.0168190 [Link]
  4. D.Schmidl, K.Witkowska, N.Luft, M.Bolz, K.Fondi, A.Bata, P.Wozniak, R.Werkmeister, G.Garhofer and L.Schmetterer
    Assessment of retinal blood flow using Laser Speckle Flowgraphy
    Acta Ophthalmologica, 95.S259, doi: 10.1111/j.1755-3768.2017.01145, 2017. [Link]
  5. Katarzyna J. Witkowska, Ahmed M. Bata, Giacomo Calzetti, Nikolaus Luft, Klemens Fondi, Piotr A. Wozniak, Doreen Schmidl, Matthias Bolz, Alina Popa-Cherecheanu, René M. Werkmeister, Gerhard Garhöfer and Leopold Schmetterer
    Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy
    PLOS ONE, 12(9), e0184772, doi: 10.1371/journal.pone.0184772, 2017. [Link]
  6. Giacomo Calzetti, Klemens Fondi, Ahmed M Bata, Nikolaus Luft, Piotr A Wozniak, Katarzyna J Witkowska, Matthias Bolz, Alina Popa-Cherecheanu, René M Werkmeister, Doreen Schmidl, Gerhard Garhöfer and Leopold Schmetterer
    Assessment of choroidal blood flow using laser speckle flowgraphy
    British Journal of Ophthalmology, bjophthalmol-2017-311750, doi: 10.1136/bjophthalmol-2017-311750, 2018. [Link]
  7. Fondi K, Bata AM, Luft N, Witkowska KJ, Werkmeister RM, Schmidl D, Bolz M, Schmetterer L and Garhöfer G
    Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy.
    PLOS ONE, 13(11), e0207525, doi:10.1371/journal.pone.0207525, 2018. [Link]
  8. Theresa Lindner, Nikolaus Hommer, Martin Kallab, Andreas Schlatter, Clemens Nadvornik, Patrick Janku, Victoria Kauer, Benedikt Rumpf, Helmuth Haslacher, Gerhard Garhöfer and Doreen Schmidl
    Retinal blood flow and oxygen saturation in patients previously infected with COVID-19
    Acta Ophthalmologica, doi: 10.1111/j.1755-3768.2022.0088, 2022. [Link]
  9. Anton B Hommer, Viktoria Pai, Patrick Janku, Theresa Lindner, Liudmyla Pylypenko, Leopold Schmetterer, Gerhard Garhofer and Doreen Schmidl
    A new approach for measuring retinal oxygen extraction based on laser speckle flowgraphy and retinal oximetry
    Investigative Ophthalmology and Visual Science, 64(8), 4738, 2023 ARVO Annual Meeting abstract, 2023.
  10. Pai Viktoria, Janku Patrick, Lindner Theresa, Graf Ulrich, Schmetterer Leopold, Garhöfer Gerhard, Schmidl Doreen
    A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry
    Trans. Vis. Sci. Tech., 13(12), 12, Dec 2024. doi:10.1167/tvst.13.12.12 [Link]
  11. Pai Viktoria, Bileck Andrea, Hommer Nikolaus, Janku Patrick, Lindner Theresa, Kauer Victoria, Rumpf Benedikt, Haslacher Helmuth, Hagn Gerhard, Meier-Menches Samuel M., Schmetterer Leopold, Schmidl Doreen, Gerner Christopher, Garhöfer Gerhard
    Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients
    Sci Rep, 14(1), Apr 2024. doi:10.1038/s41598-024-56834-4 [Link]

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Department for Ophthalmology, Kepler University Hospital

  1. Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
    Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study.
    Scientific Reports, 8(1), 5343, doi:10.1038/s41598-018-23149-0, 2018. [Link]
  2. Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
    Short-term effect on the ocular circulation inducedby unilateral intravitreal injection of aflibercept inage-related maculopathy
    Acta Ophthalmologica, doi:10.1111/aos.14098, 2019. [Link]
  3. Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
    Differences in Optic Nerve Head Blood Flow Regulation in Normal Tension Glaucoma Patients and Healthy Controls as Assessed with Laser Speckle Flowgraphy During the Water Drinking Test
    Journal of Glaucoma, doi:10.1097/IJG.0000000000001258, 2019. [Link]
  4. Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
    Effects of three intravitreal injections of aflibercept on the ocular circulation in eyes with age-related maculopathy
    British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2019-313919, 2019. [Link]
  5. A.S. Mursch-Edlmayr, L. Pickl, G. Calzetti, K. Waser, J. Wendelstein, S. Beka, V. Aranha dos Santos, N. Luft, L. Schmetterer and M. Bolz
    Comparison of neurovascular coupling between normal tension glaucoma patients and healthy individuals with Laser Speckle Flowgraphy.
    Current eye research, doi: 10.1080/02713683.2020.1752390, 2020. [Link]

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Ophthalmology Unit, University Hospital of Parma

  1. Giacomo Calzetti, Paolo Mora, Stefania Favilla, Giorgia Ottonelli, Giulia Devincenzi, Arturo Carta, Salvatore Tedesco, Anna Mursch-Edlmayr, Gerhard Garhöfer, Stefano Gandolfi, Leopold Schmetterer
    Assessment of Choroidal Neovascularization Perfusion: A Pilot Study With Laser Speckle Flowgraphy
    Translational Vision Science & Technology, 9(5), 9, doi: 10.1167/tvst.9.5.9, 2020. [Link]
  2. Giacomo Calzetti, Federica Angella, Alice Galli, Giada Marcantoni, Alessandro Romani, Mariabeatrice Simonelli, Paolo Mora, Stefano A Gandolfi, Leopold Schmetterer and Arturo Carta
    Longitudinal changes in optic nerve head perfusion in non-arteritic anterior ischemic optic neuropathy
    Investigative Ophthalmology & Visual Science, 61(7), 3951, 2020.
  3. Giacomo Calzetti, Paolo Mora, Alessandro Romani, Giorgia Ottonelli, Alessandra Pareti, Stefano Gandolfi, Leopold Schmetterer and Arturo Carta
    Optic nerve head and peripapillary perfusion as assessed with laser speckle flowgraphy in non-arteritic anterior ischaemic optic neuropathy
    Acta Ophthalmologica, 99(3), e445-e446, doi:10.1111/aos.14555, 2020. [Link]
  4. Giacomo Calzetti, Anna Sophie Mursch-Edlmayr, Ahmed M. Bata, Nicola Ungaro, Paolo Mora, Jacqueline Chua, Doreen Schmidl, Matthias Bolz, Gerhard Garhöfer, Stefano Gandolfi, Leopold Schmetterer and Damon Wong
    Measuring optic nerve head perfusion to monitor glaucoma: a study on structure-function relationships using laser speckle flowgraphy.
    Acta Ophthalmologica, doi:10.1111/aos.14862, 2021. [Link]
  5. Giacomo Calzetti, Paolo Mora, Enrico Borrelli, Riccardo Sacconi, Guido Ricciotti, Arturo Carta, Stefano Gandolfi and Giuseppe Querques
    Short-term changes in retinal and choroidal relative flow volume after anti-VEGF treatment for neovascular age-related macular degeneration
    Scientific Reports, 11(1), 1-7, 23723, doi:10.1038/s41598-021-03179-x, 2021. [Link]
  6. Matilde Longhena, Carlo Bellucci, Elisabetta Delfini, Alessandra Pareti, Stefano Gandolfi and Paolo Mora
    One-year follow up of a tobacco alcohol optic neuropathy case with atypical course: Conventional assessment and Laser speckle flowgraphy
    European Journal of Ophthalmology, doi:10.1177/11206721231160958, 2023. [Link]
  7. Fröhlich Jacqueline, Cattaneo Marco, Valmaggia Philippe, Maloca Peter M., Gugleta Konstantin, Schmetterer Leopold, Scholl Hendrik P.N., Calzetti Giacomo
    Factors Associated With Ocular Perfusion Measurements as Obtained With Laser Speckle Contrast Imaging
    Trans. Vis. Sci. Tech., 13(11), 8, Nov 2024. doi:10.1167/tvst.13.11.8 [Link]
  8. Bellucci Carlo, Virgili Medea, Romano Alessandra, Tedesco Salvatore Antonio, Mora Paolo
    Laser Speckle Flowgraphy (LSFG) in Age-Related Macular Degeneration and Diabetic Retinopathy: A Systematic Review of Recent Literature
    JCM, 14(24), 8928, Dec 2025. doi:10.3390/jcm14248928 [Link]

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Institute of Molecular and Clinical Ophthalmology Basel

  1. Giacomo Calzetti, Chiara La Morgia, Marco Cattaneo, Arturo Carta, Francesca Bosello, Giulia Amore, Michele Carbonelli, Maria Lucia Cascavilla, Stefano Gandolfi, Valerio Carelli, Leopold Schmetterer, Hendrik P. N. Scholl and Piero Barboni
    Longitudinal Study of Optic Disk Perfusion and Retinal Structure in Leber's Hereditary Optic Neuropathy
    Investigative Ophthalmology and Visual Science, 63(1), 43, doi:10.1167/iovs.63.1.43, 2022. [Link]
  2. Barbara Swiatczak, Giacomo Calzetti and Frank Schaeffel
    Axial length changes induced by positive defocus correlate with changes in choroidal blood flow
    Investigative Ophthalmology and Visual Science, 63(7), 406, 2022 ARVO Annual Meeting abstract, 2022.
  3. Barbara Swiatczak, Frank Schaeffel and Giacomo Calzetti
    Imposed positive defocus changes choroidal blood flow in young human subjects
    Graefe's Archive for Clinical and Experimental Ophthalmology, 261, 115-125, doi:10.1007/s00417-022-05842-z, 2022. [Link]
  4. Barbara Swiatczak
    Ocular blood flow and myopia
    Acta Ophthalmologica, doi:10.1111/j.1755-3768.2022.15381, 2022. [Link]

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Department of Ophthalmology, University of Zurich

  1. Anahita Bajka, Nastasia Foa, Sophia Sidhu, Magdalena Rejdak, Sadiq Said, Maximilian Robert Justus Wiest, Timothy Hamann, Frank Blaser and Sandrine Anne Zweifel
    Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy
    Klinische Monatsblätter für Augenheilkunde, 240(04), 608-612, doi:10.1055/a-2026-0924, 2023. [Link]

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Ophthalmology Clinic, Department of Medicine and Science of Ageing, University "G. d' Annunzio"

  1. Lisa Toto, Federica Evangelista, Pasquale Viggiano, Emanuele Erroi, Giada D'Onofrio, Daniele Libertini, Annamaria Porreca, Rossella D'Aloisio, Parravano Mariacristina, Luca Di Antonio, Marta Di Nicola and Rodolfo Mastropasqua
    Changes in Ocular Blood Flow after Ranibizumab IntravitrealInjection for Diabetic Macular Edema Measured Using LaserSpeckle Flowgraphy
    BioMed Research International, 2020, 9496242, doi:10.1155/2020/9496242, 2020. [Link]

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Lipoapheresis Unit, Fondazione Toscana "Gabriele Monasterio"

  1. T. Sampietro, B. Dal Pino, F. Bigazzi, F. Sbrana, A. Ripoli, E. Fontanelli, M. Pianelli, R. Luciani, A. Lepri and G. Calzetti
    Ocular microcirculation blood flow acutely increases upon cholesterol removal. The eyes mirror of the heart?
    Atherosclerosis, 355, 38-39, doi:j.atherosclerosis.2022.06.340, 2022. doi:10.1016/j.atherosclerosis.2022.06.340 [Link]
  2. T. Sampietro, B. Dal Pino, F. Bigazzi, F. Sbrana, A. Ripoli, E. Fontanelli, M. Pianelli, R. Luciani, A. Lepri and G. Calzetti
    Acute Increase in Ocular Microcirculation Blood Flow Upon Cholesterol Removal. The Eyes Are the Window of the Heart
    The American Journal of Medicine, 136(1), 108-114, doi:10.1016/j.amjmed.2022.08.016, 2022. [Link]

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Department of Ophthalmology, Rigshospitalet

  1. Jakob Wågström, Lasse Malmqvist and Steffen Hamann
    Optic Nerve Head Blood Flow Analysis in Patients with Optic Disc Drusen Using Laser Speckle Flowgraphy
    Neuro-Ophthalmology, doi:10.1080/01658107.2020.1795689, 2020. [Link]

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Ophthalmology, University Medical Center Groningen

  1. Konstantinos Pappelis, Lars Choritz and Nomdo Jansonius
    Microcirculatory model predicts blood flow and autoregulation range in the human retina: in vivo investigation with Laser Speckle Flowgraphy
    American Journal of Physiology-Heart and Circulatory Physiology, doi:10.1152/ajpheart.00404.2020, 2020. [Link]

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Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital

  1. X. Wei, A. Barathi, B.B. Sai, P.K. Balne, N. Khandelwal and R. Agrawal
    Assessment of chorioretinal blood flow and vessel diameter by laser speckle flowgraphy in three animal models
    Acta Ophthalmologica, 2016, 94.S256. doi: 10.1111/j.1755-3768.2016.0566 [Link]

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Universiti Teknologi PETRONAS

  1. M. S. Bhatti, W. Rasheed, T. B. Tang and A. Laude
    Investigating eye-strain due to prolonged exposure to low resolution multimedia using LSFG
    2016 6th International Conference on Intelligent and Advanced Systems (ICIAS), doi:10.1109/ICIAS.2016.7824096, 2016. [Link]
  2. Mehwish Saba Bhatti, Tong Boon Tang and Augustinus Laude
    Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
    PLoS ONE 12(7): e0181512. doi:10.1371/journal.pone.0181512, 2017. [Link]
  3. Mehwish Saba Bhatti, Tong Boon Tang and Hui Cheng Chen
    Ocular Blood Flow in Rabbits under Deep Anesthesia: A Real-Time Measurement Technique and Its Application in Characterizing Retinal Ischemia
    Scientific Reports, 8(1), 5713, doi:10.1038/s41598-018-24141-4, 2018. [Link]
  4. Aishah Ismail, Mehwish S. Bhatti, Ibrahima Faye, Cheng Kai Lu, Augustinus Laude and Tong Boon Tang
    Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
    Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-018-4030-9, 2018. [Link]
  5. Aishah Ismail, Tong Boon Tang, Faye Ibrahima and Chen Hui Cheng
    Animal Model - Investigation of Laser Speckle Flowgraphy for Early Carotid Artery Stenosis Detection
    2018 International Conference on Intelligent and Advanced System (ICIAS), doi:10.1109/ICIAS.2018.8540566, 2018. [Link]
  6. Aishah Ismail, Hui Cheng Chen, Ibrahima Faye and Tong Boon Tang
    Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
    Scientific Reports, 10(1), 15829, doi:10.1038/s41598-020-72556-9, 2020. [Link]

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Singapore Eye Research Institute

  1. Loo Jing Hong, Lee Ying Shi, Woon Chang Yi, Yong Victor H. K., Tan Bingyao, Schmetterer Leopold, Chong Rachel S.
    Loss of Caveolin-1 Impairs Light Flicker-Induced Neurovascular Coupling at the Optic Nerve Head
    Front. Neurosci., 15, Nov 2021. doi:10.3389/fnins.2021.764898 [Link]
  2. Sai Bo Bo Tun, Veluchamy Amutha Barathi
    Akimba Proliferative Diabetic Retinopathy Model: Understanding Molecular Mechanism and Drug Screening for the Progression of Diabetic Retinopathy
    Methods in Molecular Biology, 2678, 13-26, doi:10.1007/978-1-0716-3255-0_2, 2023. [Link]
  3. Su Zheng Zhe Steven, Ang Bryan Chin Hou, Balne Praveen Kumar, Tun Sai Bo Bo, Htoon Hla Myint, Schmetterer Leopold, Barathi Veluchamy Amutha, Agrawal Rupesh
    Effect of anti‐VEGF on retinal blood flow in diabetic mice using laser speckle flowgraphy
    Acta Ophthalmologica, 102(6), Sep 2024. doi:10.1111/aos.16672 [Link]

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Taipei Medical University

  1. Yen-Ju Chan, Po-Lin Liao, Chi-Hao Tsai, Yu-Wen Cheng, Fan-Li Lin, Jau-Der Ho, Ching-Yi Chen and Ching-Hao Li
    Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation
    Particle and fibre toxicology, 18(1), 1-16, doi:10.1186/s12989-020-00395-7, 2021. [Link]
  2. Fan-Li Lin, Yu-Wen Cheng, Li-Huei Chen, Jau-Der Ho, Jing-Lun Yen, Mong-Heng Wang, Tzong-Huei Lee and George Hsiao
    Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity
    Biomedicine and Pharmacotherapy, 158, 114138, doi:10.1016/j.biopha.2022.114138, 2022. [Link]

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Department of Ophthalmology, Chang Gung Memorial Hospital

  1. Margaret Ming-Chih Ho, Yueh-Ju Tsai, Yen-Chang Chu and Yi-Lin Liao
    Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease
    BioMed Research International, doi:10.1155/2022/9115270, 2022. [Link]
  2. Tsung‑Ying Tsai, Yueh‑Ju Tsai, Yen‑Chang Chu, Yih‑Shiou Hwang and Yi‑Lin Liao
    Ocular circulation change in optic disc melanocytoma – a case report and a review of the literature
    BMC ophthalmology, 23(1), 1-8, doi:10.1186/s12886-023-02785-9, 2023. [Link]
  3. Lin Pei-Wen, Chiu Li-Wen, Lin Chung-Wei, Chang Chun-Tuan, Lin Hsin-Ching
    Alterations on Microcirculation of Optic Nerve Head Before and After OSA Surgery
    NSS, Volume 17, 1249-1258, Jun 2025. doi:10.2147/NSS.S493508 [Link]

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Department of Ophthalmology, College of Medicine, King Saud University

  1. Ahmed M. Abu El-Asrar, Waleed Alsarhani, Abdullah Alzubaidi and Priscilla W. Gikandi
    Effect of immunosuppressive therapy on ocular blood flow in initial-onset acute uveitis associated with Vogt–Koyanagi–Harada disease.
    Acta Ophthalmologica, doi:10.1111/aos.14842, 2021. [Link]
  2. Ahmed M. Abu El-Asrar, Abdulrahman F. AlBloushi, Priscilla W. Gikandi, Abdullah Alzubaidi and Einar Stefánsson
    Changes in ocular blood flow and retinal oxygen metabolism during immunosuppressive therapy for initial-onset acute uveitis associated with Vogt–Koyanagi–Harada disease
    Acta Ophthalmologica, doi:10.1111/aos.15122, 2022. [Link]
  3. Ahmed M. Abu El-Asrar, Abdulrahman F. AlBloushi, Priscilla W. Gikandi, Abdullah Alzubaidi and Einar Stefánsson
    Acute uveitic phase of Vogt-Koyanagi-Harada disease: optic nerve head swelling, ocular blood flow and retinal oxygen metabolism
    Eye, doi:10.1038/s41433-022-02141-z, 2022. [Link]
  4. Waleed K. Alsarhani, Fadwa F. Al Adel, Abdullah Alamri, Rahaf M. Al Malawi and Abdulrahman F. AlBloushi
    Alterations in ocular microcirculation and oxygen metabolism in patients with lipemia retinalis
    BMC Ophthalmology, 22, 295, doi:10.1186/s12886-022-02515-7, 2022. [Link]

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Senju Pharmaceutical Co.,Ltd

  1. Hiroaki Takahashi, Tetsuya Sugiyama, Hideki Tokushige, Takatoshi Maeno, Toru Nakazawa, Tsunehiko Ikeda, Makoto Araie
    Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits
    Experimental Eye Research(2012), http://dx.doi.org/10.1016/j.exer.2012.12.003 doi:10.1016/j.exer.2012.12.003 [Link]
  2. Taniguchi Takazumi, Akaishi Takahiro, Hata Tatsuya, Yamashita Rieko, Esaki Yoshihiko, Morofuji Ryo, Okabe Komei, Fuwa Masahiro, Yamamoto Yasuko, Guo Li, Choi Soyoung, Luong Vy, Ota Takashi, Sharif Najam A., Cordeiro M. Francesca, Kageyama Masaaki
    Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats
    Sci Rep, 15(1), Jul 2025. doi:10.1038/s41598-025-09733-1 [Link]

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Department of Computer Science and Electronics, Kyushu Institute of Technology

  1. H.Fujii
    Visualization of retinal blood flow by laser speckle flowgraphy
    Med. Bio. Eng. & Comp., 32, no.3, 302-304, 1994.
  2. Naoki Konishi, Hitoshi Fujii
    Real-time Visualization of retinal microcirculation by laser flowgraphy
    Optical Enginnering, 34, no.3,753-757, 1995. doi:10.1117/12.195203 [Link]
  3. H. Fujii, N. Konishi, K. Okamoto and Y. Tsuchihashi
    Evaluation of Retinal Microcirculation by Real-Time Laser Flowgraphy
    Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995.
  4. Hitoshi Fujii and Naoki Konishi
    Visualization of Blood Flow Using Laser Speckle Method
    Proceedings of 18th Annual International Conference, No.688 1996. doi:10.1109/iembs.1996.656914 [Link]
  5. Hitoshi Fujii Yoshihiko Tsuchihashi and Naoki Konishi
    Evaluation of Retinal Microcirculation by Real-Time Laser Flowgraphy(II)
    Proc. 3rd Internet World Congress on Biomedical Sciences, 1996
  6. Hitoshi Fujii
    Laser Speckle Blood Flowgraphy Medical Diagnostic Techniques and Procedures, Megha Singh et.al. Ed.,
    216-224 (Narosa Publishing House, New Delhi, London, 1999)
  7. Naoki Konishi, Yoshinori Tokimoto, Kazuhiro Kohra and Hitoshi Fujii
    New Laser Speckle Flowgraphy System Using CCD Camera
    Optical Review, 9, No.4, 163-169, 2002 doi:10.1007/s10043-002-0163-4 [Link]
  8. Min-Chul Lee, Naoki Konishi and Hitoshi Fujii
    Blood Flow Analyses of Skin Tissue Under the Sacrum Using Laser Speckle Flowgraphy
    Optical Review, 10, No. 6, 562-566, 2003 doi:10.1007/s10043-003-0562-1 [Link]
  9. Lee Min-Chul, Konishi Naoki, Fujii Hitoshi
    Development of a handheld blood flow measurement system using laser speckle flowgraphy
    Opt Rev, 22(2), 308-314, Apr 2015. doi:10.1007/s10043-015-0062-0 [Link]
  10. Kenji Okamoto, Noriyoshi Takahashi, Tatsuhiko Kobayashi, Tomoaki Shiba, Yuichi Hori and Hitoshi Fujii
    Novel superpixel method to visualize fundus blood flow resistivity in healthy adults
    Scientific Reports, 13, doi:10.1038/s41598-023-33450-2, 2023. [Link]

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School of Informatics, University of Edinburgh

  1. Wu Bo
    Edge-Guided CNN-Transformer Network for Retinal Images Registration
    2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Dec 2025. doi:10.1109/BIBM66473.2025.11356576 [Link]

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ESIC Medical College, India

  1. S Thanalakshmi, Geethamahalakshmi G, Azath H., K Prabu, Kumanan T, Srinivasan C.
    Intelligent Eye Strain Relief Glasses using IoT and Naive Bayes Solutions for Digital Wellness
    2025 International Conference on Emerging Systems and Intelligent Computing (ESIC), Feb 2025. doi:10.1109/ESIC64052.2025.10962598 [Link]

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Department of Ophthalmology, Imam Mohammad Ibn Saud Islamic University

  1. Alasbali Tariq
    Current State of Knowledge in Ocular Blood Flow in Glaucoma: A Narrative Review
    OPTH, Volume 17, 2599-2607, Aug 2023. doi:10.2147/OPTH.S426709 [Link]
  2. Abu El-Asrar Ahmed M., AlBloushi Abdulrahman F., Abouammoh Marwan A., Alzubaidi Abdullah, Gikandi Priscilla W., Al Faran Abdulrahman, Al-Kharashi Abdullah S., Al-Dahmash Saad
    Comparisons of choroidal blood flow velocity between initial-onset acute uveitis associated with Vogt–Koyanagi–Harada disease and acute central serous chorioretinopathy
    Eye, 38(7), 1269-1275, May 2024. doi:10.1038/s41433-023-02879-0 [Link]

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Biological Science Laboratories, Kao Corporation

  1. Nagashima Yoshinao, Ohsugi Yuko, Niki Yoshifumi, Maeda Kouji, Okamoto Takashi
    Assessment of laser speckle flowgraphy: Development of novel cutaneous blood flow measurement technique
    SPIE Proceedings, 9792, 979218, Dec 2015. doi:10.1117/12.2203712 [Link]

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Laboratory for Memory and Cognitive Function, Keio University

  1. Masamoto Kazuto, Unekawa Miyuki, Watanabe Tatsushi, Toriumi Haruki, Takuwa Hiroyuki, Kawaguchi Hiroshi, Kanno Iwao, Matsui Ko, Tanaka Kenji F., Tomita Yutaka, Suzuki Norihiro
    Unveiling astrocytic control of cerebral blood flow with optogenetics
    Sci Rep, 5(1), Jun 2015. doi:10.1038/srep11455 [Link]

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Department of Thoracic Surgery, Dr. Lutfi Kirdar City Hospital, Istanbul

  1. Buz Mesut
    Efficacy of thoracic sympathectomy in the treatment of hyperhidrosis and management of compensatory sweating
    JOCS, 2(3), 70-71, Aug 2024. doi:10.51271/JOCS-0039 [Link]

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Nishi Eye Hospital

  1. Nishi Okihiro, Nishi Yutaro, Tatsumichi Miki, Yasukawa Tsutomu
    Pathogenesis of Pachyvein Formation in Central Serous Chorioretinopathy: A Hydrodynamic Analysis
    JCM, 13(16), 4777, Aug 2024. doi:10.3390/jcm13164777 [Link]

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Department of Ophthalmology, National Taiwan University Hospital

  1. Ho Margaret Ming-Chih, Su Wei-Wen, Cheng Yu-Chun, Yeh Po-Han, Hwang Yih-Shiou, Chen Henry Shen-Lih, Wu Wei-Chi
    Effect of latanoprostene bunod 0.024% on ocular microcirculation measured by laser speckle flowgraphy in patients with open-angle glaucoma
    Taiwan Journal of Ophthalmology, Feb 2026. doi:10.4103/tjo.TJO-D-25-00111 [Link]

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National University of Singapore

  1. Leow Y.J., Wang J.D.J., Vipin A., Sandhu G.K., Soo S.A., Kumar D., Mohammed A.A., Zailan F.Z.B., Lee F.P.H.E., Ghildiyal S., Liew S.Y., Dang C., Tanoto P., Tan I.Y.Z., Chong W.F.W., Kandiah Nagaendran
    Biomarkers and Cognition Study, Singapore (BIOCIS): Protocol, Study Design, and Preliminary Findings
    The Journal of Prevention of Alzheimer's Disease, 11(4), 1093-1105, Aug 2024. doi:10.14283/jpad.2024.89 [Link]

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Department of Plastic and Reconstructive Surgery, Shinshu University

  1. Tsunekawa Kazuhiro, Nagai Fumio, Kato Tamon, Takashimizu Ikkei, Yanagisawa Daisuke, Yuzuriha Shunsuke
    Hallucal thenar index: A new index to detect peripheral arterial disease using laser speckle flowgraphy
    Vascular, 29(1), 100-107, Feb 2021. doi:10.1177/1708538120938935 [Link]
  2. Tsunekawa Kazuhiro, Kato Tamon, Ebisawa Soichiro, Tsuzuki Shigetoshi, Takashimizu Ikkei, Yuzuriha Shunsuke
    Which plantar region can predict peripheral arterial disease by using laser speckleflowgraphy?
    Heart Vessels, 37(5), 738-744, May 2022. doi:10.1007/s00380-021-01985-x [Link]
  3. Tsunekawa Kazuhiro, Takashimizu Ikkei, Yuzuriha Shunsuke
    Prompt, Objective, and Accurate Measurement of Rat Abdominal Flap Blood Flow Using Laser Speckle Flowgraphy
    Plastic and Reconstructive Surgery - Global Open, 12(8), e6062, Aug 2024. doi:10.1097/GOX.0000000000006062 [Link]

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Laser Speckle Technique Research (General)

  1. Kusano Masashi, Nakayama Haruka, Takuwa Hiroyuki, Masamoto Kazuto, Kanno Iwao, Okada Eiji
    Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser Doppler flowmetry
    SPIE Proceedings, 8088, 80880E, Jun 2011. doi:10.1117/12.889787 [Link]
  2. Basak Kausik, Manjunatha M., Dutta Pranab Kumar
    Review of laser speckle-based analysis in medical imaging
    Med Biol Eng Comput, 50(6), 547-558, Jun 2012. doi:10.1007/s11517-012-0902-z [Link]
  3. Ansari M.Z., Nirala A.K.
    Monitoring capillary blood flow using laser speckle contrast analysis with spatial and temporal statistics
    Optik, 126(24), 5224-5229, Dec 2015. doi:10.1016/j.ijleo.2015.09.200 [Link]

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Tokyo Healthcare University

  1. Miyaji Akane, Ikemura Tsukasa, Hayashi Naoyuki
    Aging decreases CO2 reactivity in the retinal artery, but not in the ocular choroidal vessels; a cross-sectional study
    CH, 70(2), 231-240, Oct 2018. doi:10.3233/CH-170332 [Link]
  2. Miyaji Akane, Sugimori Kaori, Hayashi Naoyuki
    Short- and long-term effects of using a facial massage roller on facial skin blood flow and vascular reactivity
    Complementary Therapies in Medicine, 41, 271-276, Dec 2018. doi:10.1016/j.ctim.2018.09.009 [Link]
  3. Miyaji Akane, Hayashi Shohei, Hayashi Naoyuki
    Regional differences in facial skin blood flow responses to thermal stimulation
    Eur J Appl Physiol, 119(5), 1195-1201, May 2019. doi:10.1007/s00421-019-04109-6 [Link]

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Department of Gastrointestinal Surgery, Toho University

  1. Kaneko Tomoaki, Funahashi Kimihiko, Ushigome Mitstunori, Kagami Satoru, Yoshida Kimihiko, Koda Takamaru, Nagashima Yasuo, Miura Yasuyuki, Kurihara Akiharu, Murakami Yoshitaka
    Noninvasive assessment of bowel blood perfusion using intraoperative laser speckle flowgraphy
    Langenbecks Arch Surg, 405(6), 817-826, Sep 2020. doi:10.1007/s00423-020-01933-9 [Link]

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Department of Ophthalmology, University of Texas Medical Branch

  1. Buscho Seth E., Xia Fan, Shi Shuizhen, Lin Jonathan L., Szczesny Bartosz, Zhang Wenbo, Motamedi Massoud, Liu Hua
    Non-Invasive Evaluation of Retinal Vascular Alterations in a Mouse Model of Optic Neuritis Using Laser Speckle Flowgraphy and Optical Coherence Tomography Angiography
    Cells, 12(23), 2685, Nov 2023. doi:10.3390/cells12232685 [Link]

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Advancing fundus blood flow science

The fundus is the only place
in the body where blood vessels
can be observed directly.

Measuring not just blood flow volume, but its waveform — the quality of flow — to capture the earliest signals of vascular change. That is what LSFG makes possible.

Certified in Japan since 2008 FDA-cleared 510(k) 2016 600+ peer-reviewed publications 90+ research institutions

Softcare is the company that first commercialized LSFG technology as a certified medical device, and continues to advance it.

01 — What is blood flow?

Blood flow is the foundation of life.

Every cell in the human body depends on blood flow to receive oxygen and nutrients, and to remove metabolic waste. From the heart to the brain, to the eye, to the fingertips — blood flow sustains every organ, every moment.

01
The body's invisible infrastructure
Like the roads, water, and electricity of a city, blood flow operates silently in the background — essential, yet rarely noticed until something goes wrong.
02
Reaches every corner of the body
Oxygen and nutrients are delivered to every cell; metabolic waste is carried away. This continuous exchange is what keeps every organ functioning.
03
Change begins before symptoms appear
Just as infrastructure degrades quietly before it fails, blood flow can change long before structural damage or clinical symptoms become visible.
02 — Why does blood flow matter?

When blood flow falters,
the body suffers.

Impaired blood flow underlies many of the most serious diseases known to medicine. What these conditions share is a common origin: disruption of blood flow at the microvascular level.

Glaucoma
Reduced optic nerve head perfusion is implicated in the progression of glaucomatous damage, often preceding detectable visual field loss.
Diabetes & Metabolic Disease
Microvascular dysfunction is a hallmark of diabetic complications, affecting the fundus, kidneys, and peripheral circulation.
Cardiovascular Disease
Fundus(Retina and Choroid) blood flow waveform parameters have been shown to correlate with systemic arteriosclerosis markers including baPWV and carotid IMT.
Neurological Conditions
Cerebrovascular changes and neurodegenerative processes have been linked to alterations in fundus microcirculation.

Critically, changes in blood flow often precede structural damage. Observing blood flow continuously offers a window into the earliest stages of disease — before irreversible harm has occurred.

03 — Why waveform? Why the retina?

Flow volume tells you something.
Flow waveform tells you more.

The dynamic pattern of each cardiac cycle — systolic peaks, diastolic troughs, pulsatility indices — carries far richer data about the true condition of the microvasculature than volume alone.

Conventional assessment
Blood flow "volume"
Average velocity or perfusion volume. Tells you whether flow is high or low — but cannot reveal the dynamic behaviour of the vasculature.
LSFG assessment
Blood flow "waveform"
Beat-by-beat waveform acquisition. Systolic peak, diastolic trough, pulsatility index, waveform asymmetry — multi-dimensional vascular dynamics.
0s 2s 4s

And where is the ideal site to observe this waveform?
The Fundus (Retina and Choroid).

The fundus is the only tissue in the human body where blood vessels can be observed directly, low-invasively, and in real time. Fundus microcirculation reflects the systemic microvascular environment — making the fundus a uniquely privileged window into the body's vascular health.

04 — LSFG technology

From research
to clinical practice.

Softcare is the company that first commercialized LSFG technology as a certified medical device, and continues to advance it.

Low-invasive, 4 seconds per shot
Real-time 2D blood flow mapping
Various quantitative waveform parameters
Medical device model: LSFG-NAVI
Research models: LSFG-LITE / LSFG-Micro for animal experiments
600+
Peer-reviewed
publications
90+
Research institutions
worldwide
2008
First certified
in Japan
2016
FDA-cleared
510(k)
Learn more about our products →
LSFG-NAVI medical device
05 — Research applications

From the fundus,
a window into systemic vascular health.

LSFG technology has been utilized in a broad and growing range of research fields, reflecting the fundus's unique position as a direct and low-invasive observation point for microvascular physiology.

Ophthalmology — Glaucoma
Waveform analysis in glaucomatous damage
Waveform analysis of optic nerve head blood flow has been used to study microcirculatory changes associated with glaucomatous damage and the effects of surgical intervention.
Shiga Y et al. IOVS, 2013
Takeshima S et al. IOVS, 2019
Ophthalmology — Diabetic Retinopathy
Fundus microcirculation in diabetes
Fundus microcirculation observed by LSFG has been studied in relation to systemic vascular changes in diabetic patients, including correlations with carotid artery resistance.
Sawada S et al. Diabetes Res Clin Pract, 2020
Hanaguri J et al. Sci Rep, 2021
Ophthalmology — Retinal Vascular Occlusion
Microvascular resistance in vein occlusion
Waveform-based assessment of retinal microvascular resistance has been investigated in central and branch retinal vein occlusion, including its potential as a predictor of macular edema recurrence.
Matsumoto M et al. TVST, 2020
Hashimoto R et al. Diagnostics, 2024
Ophthalmology — Choroidal Circulation
Choroidal blood flow beyond ocular disease
Choroidal blood flow waveforms have been studied in chorioretinal diseases as well as systemic conditions such as pregnancy-induced hypertension, demonstrating the breadth of LSFG applications.
Saito M et al. IOVS, 2015
Yata K, Hashimoto R et al. AJO Case Rep, 2020
Cardiovascular Medicine
Systemic arteriosclerosis correlations
Correlations between fundus blood flow waveform parameters and systemic arteriosclerosis markers, including baPWV and carotid IMT, have been reported from multiple institutions.
Shiba T et al. Graefe's Archive, 2012
Ebuchi Y, Nagaoka T et al. Sci Rep, 2022
Neurology / Neurosurgery
Cerebrovascular monitoring
Fundus blood flow changes during carotid endarterectomy and correlations with cerebrovascular conditions have been investigated at multiple centres.
Motoyama Y et al. J Clin Monit Comput, 2020
Yoshida S et al. Acta Neurochir, 2020
Metabolic Disease
Microcirculation in systemic metabolic conditions
Studies have examined fundus microcirculation in patients with diabetes, chronic kidney disease, and metabolic syndrome across multiple institutions.
Shiba T et al. J Diabetes Res, 2017
Iwase T et al. Life, 2023
Sports Science / Preventive Medicine / Aging
Microvascular aging and exercise physiology
Fundus blood flow waveform data have been used to study physiological responses to exercise and to estimate microvascular aging using machine learning, with implications for health promotion research.
Magi S, Maruyama T et al. Sci Rep, 2026
Ikemura T, Hayashi N. Eur J Appl Physiol, 2012

Blood flow assessment holds the potential to inspire entirely new research themes — from the elucidation of disease mechanisms to a deeper understanding of human health. We look forward to the discoveries that lie ahead, together with researchers worldwide.

Blood vessels are working quietly, right now.
Our mission: to bring the technology that listens
to their voice — to the world.

Softcare Co., Ltd.

Exhibit at ARVO2026

ARVO2026

May 3-7, 2026 Denver, Colo.

Please visit our booth!

Booth# 4029

Contact us