Product Lineup for Fundus Blood Flow Assessment

One principle.
Three instruments.

All LSFG instruments share the same core technology — Laser Speckle Flowgraphy — delivering real-time, quantitative blood flow assessment across species, from laboratory to clinic.

Low-invasive measurement
Real-time 2D blood flow map
Quantitative blood flow index
Same LSFG principle across all models
Application spectrum — from basic research to clinical practice
LSFG-Micro
Mouse · Rat
LSFG-LITE
Rabbit · Pig · Monkey
LSFG-NAVI
Human · Clinical use
Basic research Clinical practice
LSFG-Micro
Research instrument
LSFG-Micro

Compact bench-top system designed for small animal research. Enables fundus blood flow measurement in mice and rats.

Mouse Rat
Application Basic research
Subject Small animals
Certification Research use
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LSFG-LITE
Research instrument
LSFG-LITE

Versatile research system supporting a broad range of animal species. Widely used in preclinical and translational research settings worldwide.

Rabbit Pig Monkey
Application Preclinical research
Subject Medium to large animals
Certification Research use
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Medical Device · JP / US
LSFG-NAVI
Medical device
LSFG-NAVI

Certified medical device for clinical use in ophthalmology and related specialties. Low-invasive real-time fundus blood flow assessment for human patients.

Human
Application Clinical & research
Subject Human
Certification Japan · US FDA 510(k)
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LSFG Flicker System

Beyond resting blood flow —
measuring the vascular response.

When the retina is exposed to flickering light, photoreceptor cells become active and demand more oxygen. Healthy blood vessels respond immediately — resistance drops and blood flow increases. This response, known as neurovascular coupling, reveals the functional state of the vascular-neural system in a way that resting blood flow measurement alone cannot.

Flicker light stimulation Photoreceptor driven signaling via Müller glia Metabolic demand ↑ Vascular dilation & increased blood flow No Flicker Flicker ON Flicker OFF 35 30 25 20 MA 0 50 100 150 200 240 Time [sec] Blood flow increased

Neurovascular coupling: flicker stimulation triggers a measurable blood flow response, which varies depending on the physiological and neurological state of the subject.

Basic research
LSFG-Micro
MouseRat

Flicker stimulation in small animal models enables investigation of neurovascular coupling at the earliest stages of disease — before clinical symptoms or functional impairment are detectable.

In diabetic model mice, the retinal blood flow response to flicker stimulation is reduced even before functional impairment becomes detectable. — Hanaguri et al., 2021
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Translational research
LSFG-LITE
RabbitPigMonkey

Supports flicker-evoked blood flow measurement in medium to large animal species, bridging the gap between rodent findings and human clinical application.

Preclinical neurovascular coupling studies in larger animal models provide critical translational data supporting clinical research and drug development.
Clinical & research
LSFG-NAVI
Human

Measures flicker-evoked retinal blood flow responses in human subjects. Response patterns reflect autonomic nervous system condition and vary with physiological state.

The response varies from morning to evening and with fatigue — offering a potential window into real-time autonomic and neurovascular status.
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The ability to provoke and measure a vascular response — not just observe resting flow — opens an entirely new dimension of physiological assessment. From bench to bedside, all three LSFG instruments bring neurovascular coupling within reach.

LSFG-Micro · LSFG-LITE · LSFG-NAVI — the same principle, across the full spectrum of research.

Exhibit at ARVO2026

ARVO2026

May 3-7, 2026 Denver, Colo.

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Booth# 4029

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