LSFG-NAVI Brochure Download


This motion picture shows the time-varying blood flow map in human retina.


Average blood flow map shown in gray scale.

Features of LSFG-NAVI

It is not necessary to use mydriatics or contrast media to do blood flow measurement with LSFG system and with a very short measurement time required, the stress of multiple measurements to a patient is minimal. After measurement, with abundant analytical functions, up to six areas of interest can be established and numerical values of blood flow in each area can be calculated. The blood flow value used in LSFG system (MBR: Mean Blur Rate) is not an absolute value of blood flow speed but a relative value. It is suitable for comparing blood flow value variations before and after treatment, medication or operation. It is also capable of analyzing the pattern of change of blood flow synchronized with a patient’s heartbeat.


Analysis Functions


Clinical Applications

Branch Retinal Vein Occlusion(BRVO)


Composite Map


Enlarged Composite Map
(Gray Scale)

Images courtesy of Department of Ophthalmology, Tokyo Women's Medical University.

English papers related to BRVO

  1. NOMA, Hidetaka, et al.
    Changes of retinal flow volume after intravitreal injection of bevacizumab in branch retinal vein occlusion with macular edema: a case series.
    BMC ophthalmology, 2016, 16.1: 1.
  2. NITTA, Fumihiko, et al.
    The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy.
    Clinical ophthalmology (Auckland, NZ), 2014, 8: 1119.
  3. MAENO, T., et al.
    Measurement of Retinal Blood Flow Volume by Laser Speckle Flowgraphy Before and After Arteriovenous Sheathotomy for Branch Retinal Vein Occlusion.
    Investigative Ophthalmology & Visual Science, 2008, 49.13: 4265-4265.


Central Retinal Vein Occlusion(CRVO)


Composite Map(before treatment)


Composite Map(after treatment)

Images courtesy of Department of Ophthalmology, Nagasaki University.

English papers related to CRVO

  1. NAGASATO, Daisuke, et al.
    Correlation between optic nerve head circulation and visual function before and after anti-VEGF therapy for central retinal vein occlusion: prospective, interventional case series.
    BMC ophthalmology, 2016, 16.1: 1.
  2. YAMADA, Yoshihisa, et al.
    Retinal blood flow correlates to aqueous vascular endothelial growth factor in central retinal vein occlusion.
    Retina, 2015, 35.10: 2037-2042.
  3. MATSUMOTO, Makiko, et al.
    Retinal blood flow levels measured by laser speckle flowgraphy in patients who received intravitreal bevacizumab injection for macular edema secondary to central retinal vein occlusion.
    Retinal Cases and Brief Reports, 2014, 8.1: 60-66.
  4. MAEDA, Kimihito; ISHIKAWA, Futoshi; OHGURO, Hiroshi.
    Ocular blood flow levels and visual prognosis in a patient with nonischemic type central retinal vein occlusion.
    Clinical ophthalmology (Auckland, NZ), 2009, 3: 489.
  5. TANO, R., et al.
    Analysis of Retinal Blood Flow by Laser Speckle Flowgraphy in a Case With Central Retinal Vein Occlusion After Radial Optic Neurotomy.
    Investigative Ophthalmology & Visual Science, 2008, 49.13: 4274-4274.

List of English Papers


Principle: Laser Speckle Flowgraphy (LSFG)
Power: AC120V, 60Hz (AC adapter: PMP90-13)
Light Source:
- Type: Laser Diode
- Wave Length: 830nm
- Class: 1 (Based on IEC60825-1:2007)
Spot size on retina: Area including macular and ONH of subjective eye with normal diopter
Output Image:
- View Angle: Maximum 21 degrees
- Resolution: 750W×360H Pixel
Time Resolution: 30Frame/sec
Safety for medical
electrical equipment:
IEC60601-1, IEC60601-1-2
Size: About 40 x 50 x 40cm
Weight: About 18kg
510(k) Number: K153239